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What do systematic reviews say?

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Evidence found and GRADE certainty

4,734 questions · 15,288 findings · 893 reviews

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No studies found 3,864 · 25.3%GRADE not reported 2,222 · 14.5%Very low 3,868 · 25.3%Low 3,280 · 21.5%Moderate 1,676 · 11%High 378 · 2.5%

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Skin care intervention vs standard skin care or no skin care intervention

Parent report of immediate reaction to common food allergen (at 2 years) · infants

Skin care intervention showed no clear difference in parent report of immediate reaction to common food allergen (at 2… compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

Allergic sensitisation to a food allergen (at 1 to 3 years) · infants

Skin care intervention showed no clear difference in allergic sensitisation to a food allergen (at 1 to 3 years) compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Cure: short‐term success · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics plus antibiotic lock solutions plus tissue… changes cure: short‐term success compared with systemic antibiotics plus antibiotic lock solutions plus heparin (very low certainty).

1 finding from 1 review

Catheter guidewire exchange vs catheter removal and replacement

Cure: infection‐free survival · patients on maintenance HD with CRBSI

It is very uncertain whether catheter guidewire exchange changes cure: infection‐free survival compared with catheter removal and replacement (very low certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Cure: long‐term success · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics plus antibiotic lock solutions plus tissue… changes cure: long‐term success compared with systemic antibiotics plus antibiotic lock solutions plus heparin (very low certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Stenosis or thrombosis of vascular access site after catheter removal · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Development of antibiotic resistance · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Systemic antibiotics alone vs systematic antibiotics plus antibiotic lock solution

Cure: successful eradication of the infection · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics alone changes cure: successful eradication of the infection compared with systematic antibiotics plus antibiotic lock solution (very low certainty).

1 finding from 1 review