Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,678 questions · 4,859 findings · 283 reviews

No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Summary of findings ‐ Inhaled mannitol plus dornase alfa vs dornase alfa

Lung function: FEF25‐75 mL/s (percentage change from baseline) · children and young adults with CF

It is very uncertain whether summary of findings ‐ Inhaled mannitol plus dornase alfa changes lung function: FEF25-75 mL/s (percentage change from baseline) compared with dornase alfa (very low certainty).

1 finding from 1 review

Psychosocial interventions vs no intervention

Point abstinence (number of participants who were abstinent at the end of the treatment) · adults with stimulant use disorder

Summary of findings table ‐ Any psychosocial intervention showed no clear difference in point abstinence, end of treatment compared with no intervention (high certainty).

1 finding from 1 review