Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

397 questions · 406 findings · 36 reviews · All outcomes

No studies found 134 · 33%GRADE not reported 184 · 45.3%Very low 59 · 14.5%Low 19 · 4.7%Moderate 10 · 2.5%High 0 · 0%

Topical anaesthetic gel (prilocaine-lidocaine) vs Eugenol

Pain at 48 hours (VAS 0-10) · Adults (>18 years) with established dry socket following permanent tooth extraction

Topical anaesthetic gel (prilocaine-lidocaine) showed no clear difference in pain at 48 hours (VAS 0-10) compared with eugenol; GRADE not reported.

1 finding from 1 review

Chlorhexidine gel (0.2%, intrasocket) vs Chlorhexidine mouthrinse

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine gel (0.2%, intrasocket) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.12%) (low certainty).

1 finding from 1 review

Tap water irrigation (monoject syringe) vs No rinsing

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tap water irrigation (monoject syringe) led to lower presence of dry socket compared with no rinsing; GRADE not reported.

1 finding from 1 review

Chlorhexidine gel vs Chlorhexidine, 0.2% to 2% (solution or gel)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine gel 1% showed no clear difference in presence of dry socket compared with chlorhexidine gel 0.2%; GRADE not reported.

1 finding from 1 review

Honey (Manuka, topical) vs Chlorhexidine rinse (0.2%)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Honey (Manuka, topical) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%); GRADE not reported.

1 finding from 1 review

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine gel (0.2%, intrasocket) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Artemisia desertorum spreng (Shahaosan) vs Artemisia desertorum spreng (Yunnan)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Shahaosan) showed no clear difference in presence of dry socket compared with artemisia desertorum spreng (Yunnan); GRADE not reported.

1 finding from 1 review

ARP with demineralised bone matrix, single particle size vs ARP with demineralised bone matrix, multiple particle size

Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review

ARP with alloplast plus barrier membrane vs ARP with alloplast without membrane

Changes in vertical height of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with alloplast plus barrier membrane changes changes in vertical height of alveolar ridge (mm) compared with ARP with alloplast without membrane (very low certainty).

1 finding from 1 review

ARP with alloplast plus barrier membrane vs ARP with alloplast without membrane

Aesthetic outcomes of future prosthodontic rehabilitation · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

The review found no eligible studies for this question.

1 finding from 1 review

ARP with allograft (bone graft) vs ARP with xenograft

Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review

ARP with allograft (bone graft) vs ARP with xenograft

Changes in vertical height of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with allograft changes changes in vertical height of alveolar ridge (mm) compared with ARP with xenograft (very low certainty).

1 finding from 1 review

ARP with demineralised bone matrix, single particle size vs ARP with demineralised bone matrix, multiple particle size

Changes in vertical height of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with demineralised bone matrix, single particle size changes changes in vertical height of alveolar ridge (mm) compared with ARP with demineralised bone matrix, multiple particle size (very low certainty).

1 finding from 1 review

ARP with allograft plus synthetic cell-binding peptide P-15 vs ARP with allograft without P-15

Implant failure rate · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

The review found no eligible studies for this question.

1 finding from 1 review

ARP with allograft plus synthetic cell-binding peptide P-15 vs ARP with allograft without P-15

Changes in bucco-lingual/palatal width of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with allograft plus synthetic cell-binding peptide P-15 changes changes in bucco-lingual/palatal width of alveolar ridge (mm) compared with ARP with allograft without P-15 (very low certainty).

1 finding from 1 review

ARP with alloplast vs ARP with xenograft

Need for additional augmentation prior to implant placement · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with alloplast changes need for additional augmentation prior to implant placement compared with ARP with xenograft (very low certainty).

1 finding from 1 review