Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

496 questions · 532 findings · 43 reviews

No studies found 136 · 25.6%GRADE not reported 22 · 4.1%Very low 136 · 25.6%Low 150 · 28.2%Moderate 68 · 12.8%High 20 · 3.8%

Non‐integrated models of care ‐ Assertive community treatment only/Intensive case management/Specialised case management services vs usual care

General life satisfaction Quality of Life Interview section, scale of 1 to 7 · people with both severe mental illness and substance misuse

The review found no eligible studies for this question.

1 finding from 1 review

CONTINGENCY MANAGEMENT vs usual care

Drug (non‐alcohol) use Number with stimulant‐positive urine test · people with both severe mental illness and substance misuse

Contingency management showed no clear difference in substance use: Drug (non‐alcohol) Number with stimulant‐positive… compared with standard care (low certainty).

1 finding from 1 review

INTEGRATED MODELS OF CARE vs usual care

Substance use: any change ‐ Alcohol use (not in remission) · people with both severe mental illness and substance misuse

Integrated models of care showed no clear difference in substance use: any change ‐ Alcohol use (not in remission) compared with standard care (low certainty).

1 finding from 1 review