Participants' assessment of global function (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral gabapentin (anticonvulsant) showed no clear difference in participants' assessment of global function (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Number of tender sites on muscles of mastication (palpation index) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral gabapentin (anticonvulsant) led to lower number of tender sites on muscles of mastication (palpation index) compared with placebo; GRADE not reported.
1 finding from 1 review
Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (horizontal - HDD) compared with non-resorbable barrier (guided bone regeneration); GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Horizontal depth of the defect (HDD).
1 study · 23 participants
GRADE not reported
Spontaneous pain in the TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral gabapentin (anticonvulsant) led to lower spontaneous pain in the TMJ (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Bio-Oss (anorganic bovine bone) showed no clear difference in bone gain (vertical - VDH) compared with bio-Oss + resorbable barrier; GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences in bone gain were found between the two procedures for vertical height of the defect (VDH) (Chen 2007).
1 study · 20 participants
GRADE not reported
Pain at rest (not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral diclofenac sodium (NSAID) showed no clear difference in pain at rest (not improved) compared with placebo; GRADE not reported.
1 finding from 1 review
Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Non-resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with resorbable barrier + autogenous bone; GRADE not reported.
1 finding from 1 review
Four complications occurred: two dehiscences in the resorbable group; one abscess and one dehiscence in the resorbable + autogenous bone group; none in the non-resorbable group. No statistically significant differences…
1 study · 25 participants
GRADE not reported
Prosthesis failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets
Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in prosthesis failure compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.
1 finding from 1 review
Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with non-resorbable barrier (guided bone regeneration); GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Vertical height of the defect (VDH).
1 study · 23 participants
GRADE not reported
Jaw pain (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral cyclobenzaprine (muscle relaxant) showed no clear difference in jaw pain (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Reduction in pain intensity · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral propranolol (beta-blocker) led to lower reduction in pain intensity (percentage of patients responding) compared with placebo; GRADE not reported.
2 findings from 1 review
Tchivileva et al 2010: a significantly greater percentage of patients (67.5% versus 32.5%) experienced reduction in pain intensity rating during the propranolol treatment period than the placebo treatment period (P =…
1 study · 40 participants
GRADE not reported
Tchivileva et al 2010: Reduction in pain intensity rating (primary outcome) comparing propranolol treatment to placebo treatment did not reach statistical significance (P = 0.104); pairwise differences between…
1 study · 40 participants
GRADE not reported
Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with resorbable barrier + autogenous bone; GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Vertical height of the defect (VDH).
1 study · 24 participants
GRADE not reported
Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (horizontal - HDD) compared with resorbable barrier + autogenous bone; GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Horizontal depth of the defect (HDD).
1 study · 24 participants
GRADE not reported
Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with resorbable barrier + autogenous bone; GRADE not reported.
1 finding from 1 review
Four complications occurred: two dehiscences in the resorbable group; one abscess and one dehiscence in the resorbable + autogenous bone group; none in the non-resorbable group. No statistically significant differences…
1 study · 24 participants
GRADE not reported
Aesthetics assessed by dentist: interproximal papilla dimension · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets
Immediate-delayed implants (placed within 8 weeks after tooth… led to lower aesthetics assessed by dentist: interproximal papilla dimension compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.
1 finding from 1 review
Implant failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets
Immediate-delayed implants (placed within 8 weeks after tooth… led to lower implant failure compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.
1 finding from 1 review
Three early implant failures (two immediate-delayed, one delayed); no statistically significant difference up to 5 years (Schropp 2003).
1 study · 46 participants
GRADE not reported
Major complication at augmented site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Bio-Oss (anorganic bovine bone) led to lower major complications at the augmented site compared with bio-Oss + resorbable barrier; GRADE not reported.
1 finding from 1 review
Two complications occurred in the Bio-Oss plus barrier group (one abscess during healing; one chronic perimplant mucositis); none in the Bio-Oss group. No statistically significant difference.
1 study · 20 participants
GRADE not reported
Jaw pain (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral clonazepam (benzodiazepine) showed no clear difference in jaw pain (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Aesthetics assessed by dentist: position of the perimplant tissues · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets
Immediate-delayed implants (placed within 8 weeks after tooth… led to higher aesthetics assessed by dentist: position of the perimplant tissues compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.
1 finding from 1 review
Reduction in pain duration (percentage of day) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral propranolol (beta-blocker) showed no clear difference in reduction in pain duration (percentage of day) compared with placebo; GRADE not reported.
1 finding from 1 review