Quality of life ‐ not reported · prevention of SCI in people with SCD and abnormal TCD velocities
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
SCD ‐ related SAEs ‐ ACS · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions
Long‐term RBC transfusions may leads to lower SCD ‐ related SAEs ‐ ACS compared with standard care (low certainty).
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions
Long‐term RBC transfusions may leads to lower SCD‐related SAEs ‐ pain crisis compared with standard care (low certainty).
1 finding from 1 review
Stroke · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions
Long‐term RBC transfusions probably leads to lower clinical stroke compared with standard care (moderate certainty).
1 finding from 1 review
Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and normalised TCD velocities
Transfusions continued may leads to lower proportion of participants developing new or progressive SCI lesions compared with transfusions halted (low certainty).
1 finding from 1 review
All‐cause mortality · prevention of SCI in people with SCD and normalised TCD velocities
It is very uncertain whether transfusions continued changes all‐cause mortality compared with transfusions halted (very low certainty).
1 finding from 1 review
All‐cause mortality · prevention of SCI in people with SCD and normal TCD velocities
1 finding from 1 review
Stroke · prevention of SCI in people with SCD and normalised TCD velocities
It is very uncertain whether transfusions continued changes clinical stroke compared with transfusions halted (very low certainty).
1 finding from 1 review
SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD and normalised TCD velocities
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and normalised TCD velocities
1 finding from 1 review
Cognitive function ‐ not reported · prevention of SCI in people with SCD and normalised TCD velocities
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life ‐ not reported · prevention of SCI in people with SCD and normalised TCD velocities
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
1 finding from 1 review
All‐cause mortality · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
1 finding from 1 review
no estimate extracted
1 study · 1 participants
Very low
SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
It is very uncertain whether hydroxyurea changes SCD‐related SAEs ‐ ACS compared with RBC transfusions (very low certainty).
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
It is very uncertain whether hydroxyurea changes SCD‐related SAEs ‐ pain crisis compared with RBC transfusions (very low certainty).
1 finding from 1 review
Stroke · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
1 finding from 1 review
SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD and normal TCD velocities
Long‐term RBC transfusion may leads to lower SCD ‐ related SAEs ‐ ACS compared with standard care (low certainty).
1 finding from 1 review
Cognitive function ‐ not reported · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life ‐ not reported · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found