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Evidence found and GRADE certainty

407 questions · 418 findings · 14 reviews · Endodontics and dental trauma

No studies found 104 · 24.9%GRADE not reported 201 · 48.1%Very low 61 · 14.6%Low 41 · 9.8%Moderate 11 · 2.6%High 0 · 0%

Guided tissue regeneration (GTR) with bovine bone mineral + resorbable collagen membrane vs No GTR (no grafting)

Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

Guided tissue regeneration (GTR) with bovine bone mineral +… showed no clear difference in healing - 1 year compared with no GTR (no grafting) (low certainty).

1 finding from 1 review

Placebo (sham irradiation, laser inactive) vs Control (no laser device used)

Maximum pain (verbal rating scale, VRS) · People requiring retreatment of periapical lesions (failed root canal therapy)

Placebo (sham irradiation, laser inactive) led to lower maximum pain (verbal rating scale, VRS) compared with control (no laser device used); GRADE not reported.

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Gutta-percha smoothing (orthograde GP root filling)

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in postoperative pain (VAS 0-100) - 1 day compared with gutta-percha smoothing (orthograde GP root filling) (low certainty).

1 finding from 1 review

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

Participants reporting swelling · People with one or more endodontically treated teeth and a periapical condition requiring retreatment
1 finding from 1 review
  • Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes
    first postoperative week
    Significantly higher number of participants reporting swelling in the root-end resection group than in the root canal retreatment group during the first postoperative week (Analysis 1.5); per-day totals not pooled.
    1 study
    GRADE not reported

Intermediate restorative material (IRM) root-end filling vs Gutta-percha

Healing - 1 year or longer · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether intermediate restorative material (IRM) root-end filling changes healing - 1 year or longer compared with gutta-percha (very low certainty).

1 finding from 1 review

Low‐level laser therapy vs Control (no laser device used)

Maximum pain (verbal rating scale, VRS) · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether low energy level laser therapy (LLLT) changes maximum pain (verbal rating scale, VRS) compared with control (no laser device used) (very low certainty).

1 finding from 1 review

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

Prevalence of pain - 1 day · People with one or more endodontically treated teeth and a periapical condition requiring retreatment

Root-end resection (with or without root-end filling; surgical… may leads to higher prevalence of pain - 1 day (participants reporting pain) compared with root canal retreatment (non-surgical/orthograde) (low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Gutta-percha smoothing (orthograde GP root filling)

Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling may leads to higher healing - 1 year compared with gutta-percha smoothing (orthograde GP root filling) (low certainty).

1 finding from 1 review

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

Healing - 1 year · People with one or more endodontically treated teeth and a periapical condition requiring retreatment

It is very uncertain whether root-end resection (with or without root-end filling; surgical… changes healing - 1 year compared with root canal retreatment (non-surgical/orthograde) (very low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Intermediate restorative material (IRM)

Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in healing - 1 year compared with intermediate restorative material (IRM) (low certainty).

1 finding from 1 review

Repositioning of ankylosed teeth after osteotomy followed or not by distraction osteogenesis, or after luxation vs Conventional orthodontic treatment or follow-up with no specific treatment for ankylosis

Outcome not reported · Any patient with ankylosis and displacement of permanent front teeth diagnosed by clinical and radiographic assessment, with or without…

The review found no eligible studies for this question.

1 finding from 1 review

Endodontic therapy (surgical or non-surgical) performed with the aid of one or more magnification devices (surgical microscope, endoscope or magnifying loupes) vs The same endodontic therapy performed without magnification devices (without visual enhancers)

Quality of root-end filling (retrograde/surgical treatment) · Patients of any age who received endodontic therapy and were followed up for at least 1 year after treatment

The review found no eligible studies for this question.

1 finding from 1 review
  • Magnification devices for endodontic therapy 2015 · Cochrane All outcomes
    No included study assessed this outcome; the review notes that such secondary outcomes were only sporadically reported and were never statistically assessed.
    Studies not reported
    No studies found

Endodontic therapy performed with one type of magnification device (surgical microscope, endoscope or magnifying loupes) vs Endodontic therapy performed with a different type of magnification device

Quality of root-end filling (retrograde/surgical treatment) · Patients of any age who received endodontic therapy and were followed up for at least 1 year after treatment

The review found no eligible studies for this question.

1 finding from 1 review
  • Magnification devices for endodontic therapy 2015 · Cochrane All outcomes
    No included study assessed this outcome; the review notes that such secondary outcomes were only sporadically reported and were never statistically assessed.
    Studies not reported
    No studies found

Root canal medications and canal filling, splinting, extraction of teeth, or surgical removal of any relevant pathology vs Each other, placebo, or no treatment

Outcome not reported · Patients with single and multiple permanent teeth with evidence of any type of external root resorption irrespective of its aetiology,…

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for the management of external root resorption 2015 · Cochrane All outcomes
    Any follow-up period
    None of the studies fulfilled our inclusion criteria and therefore no data analysis was conducted. (Main results: no RCTs that met the inclusion criteria were identified; one ongoing study, NCT00423956, potentially…
    0 studies
    No studies found

Endodontic therapy (surgical or non-surgical) performed with the aid of one or more magnification devices (surgical microscope, endoscope or magnifying loupes) vs The same endodontic therapy performed without magnification devices (without visual enhancers)

Removal of broken (fractured) instruments from the root canal · Patients of any age who received endodontic therapy and were followed up for at least 1 year after treatment

The review found no eligible studies for this question.

1 finding from 1 review
  • Magnification devices for endodontic therapy 2015 · Cochrane All outcomes
    No included study assessed this outcome; the review notes that such secondary outcomes were only sporadically reported and were never statistically assessed.
    Studies not reported
    No studies found