Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

303 questions · 321 findings · 26 reviews · Gynaecology and Fertility

No studies found 64 · 19.9%GRADE not reported 3 · 0.9%Very low 67 · 20.9%Low 104 · 32.4%Moderate 77 · 24%High 6 · 1.9%

LOD vs LOD variable energy

Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS

It is very uncertain whether LOD changes menstrual regularity at 3 months ‐ LOD unipolar vs LOD bipolar N of… compared with LOD variable energy (very low certainty).

1 finding from 1 review

LOD vs medical interventions

Improvement in androgenic symptoms · Women with symptoms of PCOS

LOD showed no clear difference in improvement in androgenic symptoms at 6 months (hirsutism/acne) ‐… compared with medical interventions (low certainty).

2 findings from 1 review

LOD vs medical interventions

Harms: GI Upset at 6 months ‐ LOD vs metformin + clomiphene N of participants: 332 (2 RCTs) Harms: OHSS rates at 6 months ‐ LOD vs gonadotrophins N of participants: 33 (1 RCT) · Women with symptoms of PCOS

LOD probably leads to lower harms: GI Upset at 6 months ‐ LOD vs metformin + clomiphene N of… compared with medical interventions (moderate certainty).

1 finding from 1 review

LOD vs other surgical interventions

Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS

LOD showed no clear difference in menstrual regularity at 6 months ‐ LOD vs ultrasound‐guided… compared with other surgical interventions (low certainty).

2 findings from 1 review

LOD vs other surgical interventions

Improvement in androgenic symptoms at 6 months (Acne) ‐ LOD vs USS guided N of participants:31 (1 RCT) · Women with symptoms of PCOS

LOD showed no clear difference in improvement in androgenic symptoms at 6 months (Acne) ‐ LOD vs USS… compared with other surgical interventions (low certainty).

1 finding from 1 review

LOD vs other surgical interventions

Improvement in androgenic symptoms at 6 months (Hirsutism) ‐ LOD vs USS‐guided N of participants: 39 (1 RCT) · Women with symptoms of PCOS

LOD showed no clear difference in improvement in androgenic symptoms at 6 months (Hirsutism) ‐ LOD vs… compared with other surgical interventions (low certainty).

1 finding from 1 review

Anterior prolapse repair: native tissue vs polypropylene mesh

De novo stress urinary incontinence review 1 to 3 years · women with anterior compartment pelvic organ prolapse

Anterior prolapse repair: native tissue showed no clear difference in stress urinary incontinence (de novo) (1‐3 years) compared with polypropylene mesh (low certainty).

1 finding from 1 review

Anterior prolapse repair: native tissue vs absorbable mesh

Recurrent anterior compartment prolapse (3 months to 2 years) · women with anterior compartment pelvic organ prolapse

Anterior prolapse repair: native tissue probably leads to higher recurrent anterior compartment prolapse (3 months to 2 years) compared with absorbable mesh (moderate certainty).

1 finding from 1 review

Anterior prolapse repair: native tissue vs biological graft

Recurrent anterior compartment prolapse (1‐2 years) · women with anterior compartment pelvic organ prolapse

Anterior prolapse repair: native tissue probably leads to higher recurrent anterior compartment prolapse (1‐2 years) compared with biological graft (moderate certainty).

1 finding from 1 review