Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,587 questions · 5,761 findings · 495 reviews

No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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Oral midazolam vs chloral hydrate

Incomplete procedure · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

Oral midazolam probably leads to higher incomplete procedures compared with chloral hydrate (moderate certainty).

1 finding from 1 review

Oral midazolam vs chloral hydrate

Anterograde amnesia (defined by number of participants who recalled the procedure) · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Disinhibition or excitation · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Patient discomfort · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Allergic or anaphylactoid reaction · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Number of days of treatment with opioid analgesics · All patients with cancer who are receiving treatment

The review found no eligible studies for this question.

2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Quality of life · All patients with cancer who are receiving treatment
2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Adverse events · All patients with cancer who are receiving treatment
2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Number of days in hospital (duration of hospitalisation) · All patients with cancer who are receiving treatment

The review found no eligible studies for this question.

2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Interruptions to cancer treatment (incidence) · All patients with cancer who are receiving treatment

The review found no eligible studies for this question.

2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Normalcy of diet (total parenteral nutrition) · All patients with cancer who are receiving treatment

It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes normalcy of diet (days of total parenteral nutrition, TPN) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (very low certainty).

2 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Duration of interruptions to cancer treatment · All patients with cancer who are receiving treatment

It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes duration of interruptions to cancer treatment compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (very low certainty).

1 finding from 1 review

Theory-based oral health education/promotion interventions (HBM, TPB, SCT, HAPA, TTM, PMT, SOC, PRECEDE-PROCEED, MI) vs Control (waitlist, routine/standard oral health education, or minimal intervention)

Mean DMFT (decayed, missing, filled permanent teeth) · school‐age children and adolescents

Theory-based interventions showed no significant effect on DMFT scores (SMD -0.11; low certainty).

1 finding from 1 review

Theory-based oral health education/promotion interventions (HBM, TPB, SCT, HAPA, TTM, PMT, SOC, PRECEDE-PROCEED, MI) vs Control (waitlist, routine/standard oral health education, or minimal intervention)

Periodontal health status · school‐age children and adolescents

Theory-based interventions significantly improved periodontal health (SMD -1.18; moderate certainty).

1 finding from 1 review

Theory-based oral health education/promotion interventions (HBM, TPB, SCT, HAPA, TTM, PMT, SOC, PRECEDE-PROCEED, MI) vs Control (waitlist, routine/standard oral health education, or minimal intervention)

Plaque index (PI) / oral hygiene · school‐age children and adolescents

Theory-based interventions significantly reduced dental plaque (SMD -1.92; moderate certainty).

1 finding from 1 review

Discussion of individual clinical photographs (plaque highlighted by a disclosing agent) as an oral hygiene motivator, plus oral hygiene instruction vs No discussion of clinical photographs, but received the same oral hygiene instruction

Plaque · People with ID (level of ID and age unclear); setting day centre

It is very uncertain whether discussion of individual clinical photographs (plaque highlighted by… changes plaque (medium term) compared with no discussion of clinical photographs, but received the same oral… (very low certainty).

1 finding from 1 review