Findings

What do systematic reviews say?

340 questions · 340 findings · 22 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 141 · 41.5%GRADE not reported 8 · 2.4%Very low 98 · 28.8%Low 57 · 16.8%Moderate 29 · 8.5%High 7 · 2.1%

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Mood or personal well‐being · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control

Mood or personal well‐being: change in distress (according to General Severity Index) · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Very low

Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control

Coping strategies · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control

QoL · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control

Physical health: number of bags of blood required, mean factor usage scores · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 44 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Coping strategies · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control

Family adjustment · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Relaxation vs no treatment

Mood or personal well‐being · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Relaxation vs no treatment

Coping strategies · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Relaxation vs no treatment

QoL · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Relaxation vs no treatment

Physical health: Reduction of bleedings, factor replacement, pain · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 7 participants
Very low

Relaxation vs no treatment

Family adjustment · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ DVD plus information booklet vs information booklet alone

QoL · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Physical health: pain intensity (VAS post‐treatment scores) · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 108 participants
Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Family adjustment · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Long‐term red cell transfusion vs usual care

Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and normal TCD velocities

Long‐term RBC transfusion showed no clear difference in proportion of participants developing new or progressive SCI lesions compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.7 [0.23, 2.13]
1 study · 196 participants
Low

Long‐term red cell transfusion vs usual care

SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD and abnormal TCD velocities

Long‐term RBC transfusion may leads to lower SCD ‐ related SAEs ‐ ACS compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.3 [0.11, 0.87]
1 study · 130 participants
Low

Long‐term red cell transfusion vs usual care

SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and abnormal TCD velocities

It is very uncertain whether long‐term RBC transfusion changes SCD‐related SAEs ‐ pain crisis compared with standard care (very low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.9 [0.44, 1.86]
1 study · 130 participants
Very low

Long‐term red cell transfusion vs usual care

Stroke · prevention of SCI in people with SCD and abnormal TCD velocities

Long‐term RBC transfusion may leads to lower clinical stroke compared with standard care (low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.1 [0.01, 0.73]
1 study · 130 participants
Low

Long‐term red cell transfusion vs usual care

Cognitive function ‐ not reported · prevention of SCI in people with SCD and abnormal TCD velocities

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found