Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

541 questions · 556 findings · 112 reviews · Headline outcomes only

No studies found 130 · 23.4%GRADE not reported 22 · 4%Very low 156 · 28.1%Low 151 · 27.2%Moderate 72 · 12.9%High 25 · 4.5%

Proton pump inhibitors (PPI) vs placebo or no prophylaxis

Clinically important upper GI bleeding · people admitted to intensive care units

Proton pump inhibitors showed no clear difference in clinically important upper GI bleeding compared with placebo or no prophylaxis (low certainty).

1 finding from 1 review