Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

High‐dose vs standard‐dose strategies

Major neurodevelopmental disability in children aged 3 to 5 years CA · preterm infants with or at risk for apnea of prematurity

The review found no eligible studies for this question.

3 findings from 1 review

High‐dose vs standard‐dose strategies

Mortality or major neurodevelopmental disability in children aged 18 to 24 months and 3 to 5 years CA · preterm infants with or at risk for apnea of prematurity

The review found no eligible studies for this question.

3 findings from 1 review

High‐dose vs standard‐dose strategies

Bronchopulmonary dysplasia/chronic lung disease · preterm infants with or at risk for apnea of prematurity

It is very uncertain whether high‐dose changes bronchopulmonary dysplasia/chronic lung disease (BPD) at 36 weeks'… compared with standard‐dose strategies (very low certainty).

3 findings from 1 review

High‐dose vs standard‐dose strategies

Length of hospital stay · preterm infants with or at risk for apnea of prematurity

The review found no eligible studies for this question.

3 findings from 1 review

High‐dose vs standard‐dose strategies

Seizures (clinically diagnosed; diagnosed by electroencephalography) · preterm infants with or at risk for apnea of prematurity

The review found no eligible studies for this question.

3 findings from 1 review

High‐dose vs low‐dose colchicine

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

High‐dose showed no clear difference in participant global assessment of treatment success: proportion with… compared with low‐dose colchicine (low certainty).

1 finding from 1 review

High‐dose vs low‐dose colchicine

Total adverse events · acute gout

High‐dose may leads to higher total adverse events compared with low‐dose colchicine (low certainty).

1 finding from 1 review