Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

428 questions · 430 findings · 82 reviews

No studies found 89 · 20.7%GRADE not reported 33 · 7.7%Very low 93 · 21.6%Low 110 · 25.6%Moderate 79 · 18.4%High 26 · 6%

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

Flutamide 250 mg once to b.i.d. showed no clear difference in participant‐reported improvement of hirsutism 4‐point Likert scale compared with spironolactone 100 mg (low certainty).

1 finding from 1 review

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg

Proportion of participants who reported an adverse event · patients with hirsutism

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg showed no clear difference in proportion of participants who reported an adverse event compared with ethinyl estradiol 30 μg + desogestrel 0.15 mg (moderate certainty).

1 finding from 1 review

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Proportion of participants who reported an adverse event · women with hirsutism

It is very uncertain whether flutamide 250 mg once to twice daily changes proportion of participants who reported an adverse event compared with metformin 1275 mg to 1700 mg per day (very low certainty).

1 finding from 1 review

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

Finasteride 5 mg showed no clear difference in participant‐reported improvement of hirsutism 4‐point Likert scale compared with flutamide 250 mg once to b.i.d. (low certainty).

1 finding from 1 review

Finasteride 5 mg vs flutamide 250 mg once to b.i.d.

Proportion of participants who reported an adverse event · women with hirsutism

It is very uncertain whether finasteride 5 mg changes proportion of participants who reported an adverse event compared with flutamide 250 mg once to b.i.d. (very low certainty).

1 finding from 1 review