Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Casirivimab/imdevimab vs placebo

Adverse events: all grades · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in adverse events: all grades within 6 months compared with placebo (low certainty).

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes serious adverse events within 6 months compared with placebo (very low certainty).

1 finding from 1 review

Tixagevimab/cilgavimab vs placebo

Development of clinical COVID‐19 symptoms within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Tixagevimab/cilgavimab leads to lower development of clinical COVID‐19 symptoms within 6 months compared with placebo (high certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Development of clinical COVID‐19 symptoms within 30 days · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab leads to lower development of clinical COVID‐19 symptoms within 30 days compared with placebo (high certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review