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What do systematic reviews say?

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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · All outcomes

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No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Occlusal adjustment (OA) vs placebo or control

Development of TMD (onset/incidence of signs and symptoms) · Healthy subjects without TMD at baseline (children, adolescents and young adults)

Occlusal adjustment (OA) showed no clear difference in incidence of TMD symptoms compared with no treatment or placebo (control); GRADE not reported.

1 finding from 1 review

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Proportion developing new caries · Children and adolescents aged 16 years or younger (permanent dentition)

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… led to lower proportion of children developing one or more new caries compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review