Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · All outcomes

No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride mouthrinse combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

1 finding from 1 review

Fluoride varnish vs Fluoride mouthrinse

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride mouthrinse; GRADE not reported.

1 finding from 1 review

Fluoride toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Proportion developing new caries · Children and adolescents aged 16 years or less

Fluoride toothpaste showed no clear difference in proportion of children developing one or more new caries compared with placebo (non-fluoride) toothpaste; GRADE not reported.

1 finding from 1 review

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less
1 finding from 1 review

Fluoride toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Acquiring extrinsic tooth staining (adverse effect; stannous fluoride toothpaste) · Children and adolescents aged 16 years or less

Fluoride toothpaste led to higher acquiring extrinsic tooth staining (adverse effect; stannous… compared with placebo (non-fluoride) toothpaste; GRADE not reported.

1 finding from 1 review

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects: dental fluorosis · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review