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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

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No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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ESA with or without iron vs no treatment

Haemoglobin response (Subnet based on 31 studies including 6985 participants) · patients at any age with solid cancer or haematological malignancy

ESA with or without iron probably leads to higher haemoglobin response (Subnet based on 31 studies including 6985… compared with no treatment (moderate certainty).

1 finding from 1 review

ESA with or without iron vs no treatment

Red blood cell transfusions (Subnet based on 69 studies including 18,684 participants) · patients at any age with solid cancer or haematological malignancy

ESA with or without iron probably leads to lower red blood cell transfusions (Subnet based on 69 studies including… compared with no treatment (moderate certainty).

1 finding from 1 review

ESA with or without iron vs no treatment

Overall mortality4 (Subnet based on 71 studies including 21,576 participants) · patients at any age with solid cancer or haematological malignancy

ESA with or without iron showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).

1 finding from 1 review

ESA with or without iron vs no treatment

Thromboembolic events · patients at any age with solid cancer or haematological malignancy

ESA with or without iron showed no clear difference in thromboembolic events5 (Subnet based on 50 studies including 15,408… compared with no treatment (moderate certainty).

1 finding from 1 review

IV or oral iron alone vs no treatment

On‐study mortality3 (Subnet based on 55 studies including 15,074 participants) · patients at any age with solid cancer or haematological malignancy

IV or oral iron alone showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).

1 finding from 1 review

Intervention not reported

Pins (No direct evidence, indirect evidence only) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether the intervention changes pins (No direct evidence, indirect evidence only) (very low certainty).

1 finding from 1 review

Intervention not reported

Screws (3 RCTs; 152 participants)a · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether the intervention changes screws (3 RCTs; 152 participants)a (very low certainty).

1 finding from 1 review

Intervention not reported

Non‐operative treatment (No direct evidence, indirect evidence only) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether the intervention changes non‐operative treatment (No direct evidence, indirect evidence only) (very low certainty).

1 finding from 1 review

Intervention not reported

Dynamic fixed angle plate (2 RCTs; 246 participants)a · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether the intervention changes dynamic fixed angle plate (2 RCTs; 246 participants)a (very low certainty).

1 finding from 1 review