Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,751 questions · 12,775 findings · 807 reviews · Headline outcomes only

No studies found 3,413 · 26.7%GRADE not reported 709 · 5.5%Very low 3,483 · 27.3%Low 3,165 · 24.8%Moderate 1,628 · 12.7%High 377 · 3%

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Mood stabilisers vs placebo

Self‐harm Measured by: clinicians Timing of outcome assessment: end of treatment · patients with borderline personality disorder

It is very uncertain whether mood stabilisers changes self‐harm Timing of outcome assessment: end of treatment (52 weeks… compared with placebo (very low certainty).

1 finding from 1 review

Antipsychotics vs placebo

Self‐harm Measured by: clinicians Timing of outcome assessment: end of treatment · patients with borderline personality disorder

It is very uncertain whether antipsychotics changes self‐harm Timing of outcome assessment: end of treatment (8 to 24… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Knowledge and understanding Variable scales: information (amount and type) needs/preferences; discordance between patient and physician survival and curability estimates Timing: immediately to 1 month post‐consultation · people approaching the end of life (within 12 months), their family members and/or carers
1 finding from 1 review

Intervention not reported

Evaluation of the communication: different constructs (perceptions of communication quality; patient‐centredness of communication; involvement preferences; doctor‐patient relationship measures) Timing: immediately post‐consultation to 18 weeks pos... · people approaching the end of life (within 12 months), their family members and/or carers
1 finding from 1 review

Intervention not reported

Discussions of EoL/EoL care: discussion timing and length EMR review post‐death Timing: at time of family conference (intervention) in ICU; post‐death  · people approaching the end of life (within 12 months), their family members and/or carers
1 finding from 1 review

Intervention not reported

Discussions of EoL/EoL care: discussion occurrence EMR review post‐death; coding of consultations; self‐reported occurrence Timing: immediately, 1 or 2 weeks post‐consultation; after death · people approaching the end of life (within 12 months), their family members and/or carers
1 finding from 1 review

Corticosteroids vs no corticosteroid use

Disease‐specific mortality ‐ SJS and TEN (time to · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

It is very uncertain whether corticosteroids changes disease‐specific mortality ‐ SJS and TEN (time to compared with no corticosteroids (very low certainty).

1 finding from 1 review