Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

761 questions · 801 findings · 50 reviews · Common Mental Disorders

No studies found 125 · 15.6%GRADE not reported 34 · 4.2%Very low 226 · 28.2%Low 232 · 29%Moderate 176 · 22%High 8 · 1%

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Secondary outcome: acceptability of treatment · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes acceptability Participants dropping out of treatment during the… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

> 50% reduction in depressive symptoms · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes proportions of participants responding to treatment ≥ 50% reduction… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review