Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · All outcomes

No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Yangyin-humo decoction vs Traditional Western medicine

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Yangyin-humo decoction showed no clear difference in oral mucositis (severe) compared with traditional Western medicine; GRADE not reported.

1 finding from 1 review

Radiotherapy (morning) vs Radiotherapy (afternoon/evening)

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Radiotherapy (morning) showed no clear difference in oral mucositis (moderate to severe) compared with radiotherapy (afternoon/evening); GRADE not reported.

1 finding from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no treatment

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) led to lower oral mucositis (moderate to severe) compared with no treatment; GRADE not reported.

1 finding from 1 review

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Fluorosis (adverse effect; % of children with fluorotic teeth) · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
2 findings from 1 review

Chinese herbal medicines vs Control (Dobell's solution)

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chinese herbs (medicine) led to lower oral mucositis (moderate to severe) compared with control (Dobell's solution); GRADE not reported.

1 finding from 1 review

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (moderate to severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs No fluoride supplement (placebo or no treatment)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
3 findings from 1 review