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Summary of findings table ‐ Fitusiran prophylaxis probably leads to higher all adverse events compared with on‐demand therapy (moderate certainty).
Summary of findings table ‐ Fitusiran prophylaxis showed no clear difference in adverse events ‐ Serious adverse events compared with on‐demand therapy (moderate certainty).
Summary of findings table ‐ Emicizumab prophylaxis probably leads to higher all adverse events compared with on‐demand therapy (moderate certainty).
Summary of findings table ‐ Emicizumab prophylaxis showed no clear difference in serious adverse events compared with on‐demand therapy (moderate certainty).
It is very uncertain whether occlusal splint changes frequency of joint noise compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).
Occlusal splint showed no clear difference in range of mandibular motion compared with behavioural therapy (counselling, CBT, relaxation, self-care…; GRADE not reported.
It is very uncertain whether occlusal splint changes joint pain at rest compared with pharmacological therapy (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether occlusal splint changes muscle pain at rest compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).
The review found no eligible studies for this question.
Occlusal splint showed no clear difference in somatisation compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.
The review found no eligible studies for this question.
Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with behavioural therapy (counselling, CBT, relaxation, self-care…; GRADE not reported.
Occlusal splint showed no clear difference in range of mandibular motion compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.
Surgery showed no clear difference in total mortality compared with radiotherapy alone (low certainty).
The review found no eligible studies for this question.