Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,751 questions · 12,775 findings · 807 reviews · Headline outcomes only

No studies found 3,413 · 26.7%GRADE not reported 709 · 5.5%Very low 3,483 · 27.3%Low 3,165 · 24.8%Moderate 1,628 · 12.7%High 377 · 3%

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Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Eradication of MRSA · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in eradication of MRSA compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Time until next positive MRSA isolate (from clinically relevant respiratory culture) · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Retrograde intramedullary nail (RIMN) vs locking plate

Direct adverse events (reoperation): we report reoperation for removal of implant as this is the most clinically relevant. Other adverse events with data included: loss of fixation, superficial infection, deep infection, haematoma formation, impla... · adults with fractures of the distal femur

It is very uncertain whether retrograde intramedullary nail (RIMN) changes direct adverse events (reoperation): we report reoperation for… compared with locking plate (very low certainty).

1 finding from 1 review