Continuous infusion vs forced (or pulse) infusion of thrombolytic agents
Amputation · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted3 studies · 164 participantsVery low
Findings
What do systematic reviews say?
4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only
No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%
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Continuous infusion vs forced (or pulse) infusion of thrombolytic agents
30‐Day mortality · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 304 participantsVery low
Continuous infusion vs forced (or pulse) infusion of thrombolytic agents
Vessel patency (up to 30 days) · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 304 participantsVery low
Continuous infusion vs forced (or pulse) infusion of thrombolytic agents
Duration of thrombolysis (to end of treatment) · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 304 participantsVery low
Continuous infusion vs forced (or pulse) infusion of thrombolytic agents
Stroke · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 304 participantsVery low
Continuous infusion vs forced (or pulse) infusion of thrombolytic agents
Major bleeding · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 304 participantsVery low
Intervention not reported
30‐Day amputation‐free survival · patients with less than 42 days' lower limb ischaemia
1 finding from 1 review
- no estimate extracted1 study · 70 participantsGRADE not reported
Intervention not reported
Amputation ( · patients with less than 42 days' lower limb ischaemia
1 finding from 1 review
- no estimate extracted1 study · 70 participantsGRADE not reported
Intervention not reported
30‐Day mortality · patients with less than 42 days' lower limb ischaemia
1 finding from 1 review
- no estimate extracted1 study · 70 participantsGRADE not reported
Intervention not reported
Vessel patency ( · patients with less than 42 days' lower limb ischaemia
It is very uncertain whether the intervention changes vessel patency ( (very low certainty).
1 finding from 1 review
- OR 1.2 [0.39, 3.69]1 study · 70 participantsVery low
Intervention not reported
Duration of thrombolysis ( · patients with less than 42 days' lower limb ischaemia
1 finding from 1 review
- no estimate extracted1 study · 70 participantsLow
Intervention not reported
CVA ( · patients with less than 42 days' lower limb ischaemia
1 finding from 1 review
- no estimate extracted1 study · 70 participantsLow
Intervention not reported
Major bleeding ( · patients with less than 42 days' lower limb ischaemia
It is very uncertain whether the intervention changes major bleeding ( (very low certainty).
1 finding from 1 review
- OR 0.25 [0.01, 4.9]1 study · 70 participantsVery low
High‐dose vs low‐dose regimens of thrombolytic agents
30‐Day amputation‐free survival · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 302 participantsVery low
High‐dose vs low‐dose regimens of thrombolytic agents
Amputation · patients with < 42 days' limb ischaemiaa
1 finding from 1 review
- no estimate extracted4 studies · 302 participantsVery low
Topical ointment or cream vs routine skin care
Invasive infection (before hospital discharge) · preterm infants with low birth weight
Topical ointment or cream showed no clear difference in invasive infection until hospital discharge compared with routine skin care (low certainty).
1 finding from 1 review
- Topical emollient for preventing infection in preterm infants 2021 · Cochrane Headline outcomes onlyRR 1.13 [0.97, 1.31]8 studies · 2086 participantsLow
Topical ointment or cream vs routine skin care
Mortality before hospital discharge · preterm infants with low birth weight
Topical ointment or cream showed no clear difference in mortality until hospital discharge (or latest reported) compared with routine skin care (low certainty).
1 finding from 1 review
- Topical emollient for preventing infection in preterm infants 2021 · Cochrane Headline outcomes onlyRR 0.87 [0.75, 1.03]7 studies · 2067 participantsLow
Topical oil vs routine skin care
Invasive infection (any organism) · preterm infants with low birth weight
Topical oil may leads to lower invasive infectionuntil hospital discharge compared with routine skin care (low certainty).
1 finding from 1 review
- Topical emollient for preventing infection in preterm infants 2021 · Cochrane Headline outcomes onlyRR 0.71 [0.52, 0.96]9 studies · 3256 participantsLow
Topical oil vs routine skin care
Mortality before hospital discharge · preterm infants with low birth weight
Topical oil showed no clear difference in mortality until hospital discharge (or latest reported) compared with routine skin care (low certainty).
1 finding from 1 review
- Topical emollient for preventing infection in preterm infants 2021 · Cochrane Headline outcomes onlyRR 0.94 [0.82, 1.08]11 studies · 1119 participantsLow
Topical ointment or cream vs oil
Invasive infection (any organism) · preterm infants with low birth weight
Topical ointment or cream showed no clear difference in invasive infectionuntil hospital discharge compared with oil (low certainty).
1 finding from 1 review
- Topical emollient for preventing infection in preterm infants 2021 · Cochrane Headline outcomes onlyRR 0.91 [0.57, 1.46]1 study · 316 participantsLow