Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Intervention not reported

MMRV randomised controlled trial ‐ any severity ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ any severity ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

Cohort studies ‐ 2 doses · children 9 months to 15 years old

The intervention probably leads to lower cohort studies ‐ 2 doses (moderate certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ any severity ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ any severity ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ any severity ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ any severity ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ any severity ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ any severity ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMR+V randomised controlled trial ‐ moderate/severe cases ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

Temperature ‐ RCT/CCT axillary · children 9 months to 15 years old

The intervention may leads to higher temperature ‐ RCT/CCT axillary (low certainty).

1 finding from 1 review

Intervention not reported

Temperature ‐ RCT/CCT rectal · children 9 months to 15 years old

The intervention showed no clear difference in temperature ‐ RCT/CCT rectal (low certainty).

1 finding from 1 review

Intervention not reported

Cohort studies household contacts ‐ 1 dose · children 9 months to 15 years old

The intervention may leads to lower cohort studies household contacts ‐ 1 dose (low certainty).

1 finding from 1 review

Intervention not reported

Temperature ‐ RCT/CCT measurement site not reported · children 9 months to 15 years old

The intervention showed no clear difference in temperature ‐ RCT/CCT measurement site not reported (high certainty).

1 finding from 1 review

Intervention not reported

Temperature ‐ cohort studies orally · children 9 months to 15 years old

It is very uncertain whether the intervention changes temperature ‐ cohort studies orally (very low certainty).

1 finding from 1 review

Intervention not reported

Temperature ‐ cohort studies measurement site not reported · children 9 months to 15 years old

It is very uncertain whether the intervention changes temperature ‐ cohort studies measurement site not reported (very low certainty).

1 finding from 1 review

Intervention not reported

Rash ‐ cohort studies · children 9 months to 15 years old

It is very uncertain whether the intervention changes rash ‐ cohort studies (very low certainty).

1 finding from 1 review

Intervention not reported

Lymphadenopathy ‐ RCT/CCT · children 9 months to 15 years old

The intervention showed no clear difference in lymphadenopathy ‐ RCT/CCT (moderate certainty).

1 finding from 1 review

Intervention not reported

Lymphadenopathy ‐ cohort studies · children 9 months to 15 years old

It is very uncertain whether the intervention changes lymphadenopathy ‐ cohort studies (very low certainty).

1 finding from 1 review