Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Intervention not reported

Cohort studies ‐ 1 dose · children 9 months to 15 years old

The intervention probably leads to lower cohort studies ‐ 1 dose (moderate certainty).

1 finding from 1 review

Intervention not reported

Cohort studies ‐ Jeryl Lynn strain ‐ household contacts · children 9 months to 15 years old

The intervention probably leads to lower cohort studies ‐ Jeryl Lynn strain ‐ household contacts (moderate certainty).

1 finding from 1 review

Intervention not reported

Self‐controlled case series ‐ encephalitis meningitis ‐ encephalitis meningitis risk period (0 to 90 days) · children 9 months to 15 years old

The intervention showed no clear difference in self‐controlled case series ‐ encephalitis meningitis ‐ encephalitis… (low certainty).

1 finding from 1 review

Intervention not reported

Self‐controlled case series ‐ herpes ‐ herpes risk period (0 to 90 days) · children 9 months to 15 years old

The intervention showed no clear difference in self‐controlled case series ‐ herpes ‐ herpes risk period (0 to 90… (low certainty).

1 finding from 1 review

Intervention not reported

Self‐controlled case series ‐ pneumonia ‐ pneumonia risk period (0 to 90 days) · children 9 months to 15 years old

The intervention showed no clear difference in self‐controlled case series ‐ pneumonia ‐ pneumonia risk period (0… (low certainty).

1 finding from 1 review

Intervention not reported

Self‐controlled case series ‐ miscellaneous viral infections ‐ miscellaneous viral infections risk period (0 to 90 days) · children 9 months to 15 years old

The intervention showed no clear difference in self‐controlled case series ‐ miscellaneous viral infections ‐… (low certainty).

1 finding from 1 review

Intervention not reported

Cohort studies ‐ Urabe strain ‐ unspecified numbers or at least 1 dose · children 9 months to 15 years old

The intervention may leads to lower cohort studies ‐ Urabe strain ‐ unspecified numbers or at least 1 dose (low certainty).

1 finding from 1 review

Intervention not reported

Cohort studies ‐ Rubini strain ‐ unspecified numbers or at least 1 dose · children 9 months to 15 years old

The intervention showed no clear difference in cohort studies ‐ Rubini strain ‐ unspecified numbers or at least 1… (low certainty).

1 finding from 1 review

Intervention not reported

Cohort studies ‐ mumps strain not reported or any strain · children 9 months to 15 years old

The intervention may leads to lower cohort studies ‐ mumps strain not reported or any strain (low certainty).

1 finding from 1 review

Intervention not reported

Cohort studies ‐ third dose versus 2 doses · children 9 months to 15 years old

The intervention showed no clear difference in cohort studies ‐ third dose versus 2 doses (low certainty).

1 finding from 1 review

Intervention not reported

Cohort studies secondary cases ‐ any strain · children 9 months to 15 years old

The intervention probably leads to lower cohort studies secondary cases ‐ any strain (moderate certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ any severity ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ any severity ‐ 2 doses ‐ (high certainty).

1 finding from 1 review

Intervention not reported

MMRV randomised controlled trial ‐ any severity ‐ 2 doses ‐ · children 9 months to 15 years old

The intervention leads to lower MMRV randomised controlled trial ‐ any severity ‐ 2 doses ‐ (high certainty).

1 finding from 1 review