Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

5‐ASA vs placebo

Relapse, drop‐outs classed as relapse, grouped by length of · patients with maintenance of medically‐induced remission in Crohn's disease

5‐ASA showed no clear difference in relapse, drop‐outs classed as relapse, grouped by length of compared with placebo (moderate certainty).

3 findings from 1 review

Intervention not reported

Duration of diarrhoea · children with acute diarrhoea

The intervention showed no clear difference in duration of diarrhoea (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children aged less than 6 months with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review