What do systematic reviews say?

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Taxane followed by anthracyclines showed no clear difference in adverse events: neutropenia (grade 3/4) ( compared with anthracyclines followed by taxane (moderate certainty).

• Sequencing of anthracyclines and taxanes in neoadjuvant and adjuvant therapy for early breast cancer 2019 · Cochrane Headline outcomes only
  RR 1.25 [0.86, 1.82]
  1 study · 280 participants
  Moderate

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Taxane followed by anthracyclines showed no clear difference in adverse events: neurotoxicity (grade 3/4) ( compared with anthracyclines followed by taxane (low certainty).

• Sequencing of anthracyclines and taxanes in neoadjuvant and adjuvant therapy for early breast cancer 2019 · Cochrane Headline outcomes only
  RR 0.95 [0.55, 1.65]
  2 studies · 1108 participants
  Low

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Taxane followed by anthracyclines showed no clear difference in treatment adherence (defined as dose reduction) ( compared with anthracyclines followed by taxane (moderate certainty).

• Sequencing of anthracyclines and taxanes in neoadjuvant and adjuvant therapy for early breast cancer 2019 · Cochrane Headline outcomes only
  RR 0.81 [0.59, 1.11]
  1 study · 280 participants
  Moderate

Taxane followed by anthracyclines vs anthracyclines followed by taxane

The review found no eligible studies for this question.

• Sequencing of anthracyclines and taxanes in neoadjuvant and adjuvant therapy for early breast cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Taxane followed by anthracyclines vs anthracyclines followed by taxane

The review found no eligible studies for this question.

• Sequencing of anthracyclines and taxanes in neoadjuvant and adjuvant therapy for early breast cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Taxane followed by anthracyclines vs anthracyclines followed by taxane

The review found no eligible studies for this question.

• Sequencing of anthracyclines and taxanes in neoadjuvant and adjuvant therapy for early breast cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

PRP (platelet-rich plasma) in cellulose foam placed in extraction socket vs placebo, no treatment or surveillance only

It is very uncertain whether PRP (platelet-rich plasma) in cellulose foam placed in extraction… changes incidence of ORN compared with no treatment/placebo (cellulose foam only) placed in extraction socket (very low certainty).

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  5-year follow-up
  OR 3.32 [0.58, 19.09]
  1 study · 44 participants
  Very low

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs High-content fluoride toothpaste (1350 ppm)

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  14 to 36 months
  This comparison was only made in 1 study, which showed no difference between the 2 interventions: no patients in either group developed ORN (12- to 36-month follow-up) (0/99 in the fluoride gel group and 0/91 in the…
  1 study · 220 participants
  Very low

PRP (platelet-rich plasma) in cellulose foam placed in extraction socket vs placebo, no treatment or surveillance only

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  2 weeks to 12 months
  This comparison was only made in 1 study: mean pain scores at 2 weeks, 2, 6, 9, and 12 months showed no 'significant' differences between the 2 groups (self-reported Likert scale 1 to 10; difference at 2 weeks P =…
  1 study · 44 participants
  Very low

SPT using one technique or appliance for mechanical root debridement vs SPT using a different technique or appliance for mechanical root debridement

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

It is very uncertain whether SPT performed by non-specialist clinicians (general dental… changes bleeding on probing (%) compared with SPT performed by specialists (specialist practice) (very low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD 7.40 [-8.12, 22.92]
  1 study · 35 participants
  Very low

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

It is very uncertain whether SPT performed by non-specialist clinicians (general dental… changes probing pocket depth (mm) compared with SPT performed by specialists (specialist practice) (very low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD 0.20 [-0.40, 0.80]
  1 study · 35 participants
  Very low

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

It is very uncertain whether mechanical debridement plus local antimicrobial (minocycline… changes bleeding on probing (ratios) compared with mechanical debridement alone (very low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  OR 0.45 [0.14, 1.52]
  1 study · 50 participants
  Very low

SPT provided at one time interval vs SPT provided at a different time interval

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  See comment. Killeen 2016 reported no adverse events at follow-up examinations in either study arm. Tonetti 2012 reported that there were no serious adverse events.
  2 studies · 251 participants
  GRADE not reported

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in pocket depth (mm) compared with mechanical debridement alone (low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD -0.10 [-0.59, 0.39]
  1 study · 51 participants
  Low

Sodium valproate vs phenytoin monotherapy

Sodium valproate showed no clear difference in time to treatment failure (any reason related to treatment) All… compared with phenytoin monotherapy (moderate certainty).

• Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
  HR 0.88 [0.61, 1.27]
  5 studies · 528 participants
  Moderate

Sodium valproate vs phenytoin monotherapy

Sodium valproate showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenytoin monotherapy (moderate certainty).

• Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
  HR 0.83 [0.5, 1.38]
  4 studies · 187 participants
  Moderate

Sodium valproate vs phenytoin monotherapy

Sodium valproate showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenytoin monotherapy (low certainty).

• Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
  HR 0.94 [0.55, 1.61]
  5 studies · 341 participants
  Low