Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,973 questions · 3,072 findings · 410 reviews · Headline outcomes only

No studies found 559 · 18.2%GRADE not reported 143 · 4.7%Very low 654 · 21.3%Low 833 · 27.1%Moderate 683 · 22.2%High 200 · 6.5%

SCS treatment for 7 or fewer days vs SCS treatment

Treatment failure Need for additional treatment · exacerbations of COPD

SCS treatment for 7 or fewer days showed no clear difference in treatment failure Need for additional treatment compared with SCS treatment (moderate certainty).

1 finding from 1 review

SCS treatment for 7 or fewer days vs SCS treatment

Relapse New acute exacerbation or COPD‐related admission · exacerbations of COPD

SCS treatment for 7 or fewer days showed no clear difference in relapse New acute exacerbation or COPD‐related admission compared with SCS treatment (moderate certainty).

1 finding from 1 review

SCS treatment for 7 or fewer days vs SCS treatment

Adverse drug effects Gastrointestinal tract bleeding, symptomatic gastrointestinal reflux, symptoms of congestive heart failure or ischaemic heart disease, sleep disturbance, fractures, depression · exacerbations of COPD

SCS treatment for 7 or fewer days showed no clear difference in adverse drug effects Gastrointestinal tract bleeding, symptomatic… compared with SCS treatment (low certainty).

1 finding from 1 review