Hydroxyurea vs no hydroxyurea
Death during the study · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 44 participantsVery low
Findings
What do systematic reviews say?
873 questions · 883 findings · 38 reviews · Cystic Fibrosis and Genetic Disorders
No studies found 319 · 36.1%GRADE not reported 18 · 2%Very low 198 · 22.4%Low 186 · 21.1%Moderate 147 · 16.6%High 15 · 1.7%
Hydroxyurea vs no hydroxyurea
Measures of HbF · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 44 participantsVery low
Hydroxyurea vs no hydroxyurea
Measures of ANC · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 44 participantsVery low
Hydroxyurea vs no hydroxyurea
Quality of life · people with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Hydroxyurea vs no hydroxyurea
Adverse events or toxicity · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 44 participantsVery low
Hydroxyurea vs placebo
All‐cause mortality · people with sickle cell disease
Summary of findings ‐ Hydroxyurea showed no clear difference in death during the study (all deaths) compared with placebo (moderate certainty).
1 finding from 1 review · compare the 2 reviews
- RR 0.65 [0.19, 2.27]5 studies · 784 participantsModerate
Hydroxyurea vs placebo
Measures of HbF · people with sickle cell disease
1 finding from 1 review
- no estimate extracted5 studies · 784 participantsLow
Hydroxyurea vs placebo
Measures of ANC · people with sickle cell disease
1 finding from 1 review
- no estimate extracted4 studies · 724 participantsModerate
Hydroxyurea vs placebo
Health status and quality of life · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 277 participantsLow
Hydroxyurea vs placebo
Adverse events or toxicity: differences in rates of specific adverse events · people with sickle cell disease
1 finding from 1 review
- no estimate extracted5 studies · 784 participantsLow
Summary of findings: nitric oxide vs placebo
Pulmonary exacerbations · children (12 or over) and young adults with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Summary of findings: nitric oxide vs placebo
FEV1 (% predicted): mean change from baseline · children (12 or over) and young adults with cystic fibrosis
Summary of findings: nitric oxide showed no clear difference in respiratory function mean change in FEV1 % predicted from baseline compared with placebo (low certainty).
1 finding from 1 review
- Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 12 participantsLow
Summary of findings: nitric oxide vs placebo
Adverse events · children (12 or over) and young adults with cystic fibrosis
It is very uncertain whether summary of findings: nitric oxide changes adverse events compared with placebo (very low certainty).
1 finding from 1 review
- Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis 2020 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 30 participantsVery low
Summary of findings: nitric oxide vs placebo
Need for antibiotics · children (12 or over) and young adults with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Summary of findings: nitric oxide vs placebo
QoL · children (12 or over) and young adults with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Summary of findings: nitric oxide vs placebo
Sputum microbiology · children (12 or over) and young adults with cystic fibrosis
1 finding from 1 review
- Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis 2020 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 30 participantsVery low
Summary of findings: nitric oxide vs placebo
Inflammatory markers · children (12 or over) and young adults with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Summary of findings: ECM vs a different ECM
Change in weight (kg) · adults and children with cystic fibrosis
Summary of findings: ECM (Creon®) showed no clear difference in change in weight (kg) compared with a different ECM (moderate certainty).
1 finding from 1 review
- Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes onlyMD 01 study · 83 participantsModerate
Summary of findings: ECM vs a different ECM
Change in height · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Summary of findings: ECM vs a different ECM
Change in BMI · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found