Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

306 questions · 324 findings · 26 reviews

No studies found 59 · 18.2%GRADE not reported 30 · 9.3%Very low 91 · 28.1%Low 62 · 19.1%Moderate 78 · 24.1%High 4 · 1.2%

QUETIAPINE vs RISPERIDONE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

QUETIAPINE probably leads to lower adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson… compared with RISPERIDONE (moderate certainty).

1 finding from 1 review

QUETIAPINE vs RISPERIDONE

Adverse effects: 3. Metabolic weight gain ≥7% of total body weight · schizophrenia

QUETIAPINE showed no clear difference in adverse effects: 3. Metabolic weight gain ≥7% of total body weight compared with RISPERIDONE (moderate certainty).

1 finding from 1 review

SWITCHING ANTIPSYCHOTIC: TO OLANZAPINE vs MAINTENANCE RISPERIDONE/FGA

Leaving the study early · patients with sexual dysfunction due to antipsychotic drug therapy

It is very uncertain whether SWITCHING ANTIPSYCHOTIC: TO OLANZAPINE changes leaving the study early compared with MAINTENANCE RISPERIDONE/FGA (very low certainty).

1 finding from 1 review

Paliperidone palmitate vs risperidone long‐acting injection

No clinically important change Number of people whose PANSS score either increased or did not decrease by at least 30% from the beginning to the end of the trial · patients with schizophrenia

Paliperidone palmitate showed no clear difference in no clinically important change Number of people whose PANSS score… compared with risperidone long‐acting injection (low certainty).

1 finding from 1 review

Paliperidone palmitate vs risperidone long‐acting injection

Relapse: recurrence of psychotic symptoms Reported by trial author as adverse event · patients with schizophrenia

Paliperidone palmitate showed no clear difference in relapse: recurrence of psychotic symptoms Reported by trial authors… compared with risperidone long‐acting injection (moderate certainty).

1 finding from 1 review