Drop‐out Objective · Adults with mental disorders in low‐ and middle‐income countries
Metformin showed no clear difference in drop‐outs (12 to 14 weeks) compared with placebo (moderate certainty).
1 finding from 1 review
Fasting blood glucose (mg/dL) · Adults with mental disorders in low‐ and middle‐income countries
2 findings from 1 review
Body‐mass index (BMI) · Adults with mental disorders in low‐ and middle‐income countries
1 finding from 1 review
Depression response (acute phase, 5 ≤ 12 weeks) · women of any age, with PND up to 12 months
Antidepressants showed no clear difference in depression response (acute, 5 ≤ 12 weeks) compared with placebo (low certainty).
1 finding from 1 review
RR 1.27 [0.97, 1.66]
Studies not reported
Low
Depression remission · women of any age, with PND up to 12 months
Antidepressants showed no clear difference in depression remission (acute, 5 ≤ 12 weeks) compared with placebo (low certainty).
1 finding from 1 review
RR 1.54 [0.99, 2.41]
Studies not reported
Low
Adverse events · women of any age, with PND up to 12 months
Antidepressants may leads to lower adverse events compared with placebo (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Depression severity (acute phase, 5 ≤ 12 weeks) · women of any age, with PND up to 12 months
2 findings from 1 review
no estimate extracted
Studies not reported
Low
no estimate extracted
Studies not reported
Low
Acceptability ‐ total dropouts · women of any age, with PND up to 12 months
Antidepressants showed no clear difference in treatment acceptability ‐ dropouts compared with placebo (low certainty).
1 finding from 1 review
RR 1.1 [0.74, 1.64]
Studies not reported
Low
Child‐related outcomes · women of any age, with PND up to 12 months
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrence of any episodes at one year (hospitalization for any episodes) · bipolar disorder
1 finding from 1 review
Recurrence of manic episode at one year · bipolar disorder
Lamotrigine showed no clear difference in recurrence of manic episode at one year compared with placebo (moderate certainty).
1 finding from 1 review
Recurrence of depressive episode at one year · bipolar disorder
Lamotrigine showed no clear difference in recurrence of depressive episode at one year compared with placebo (moderate certainty).
1 finding from 1 review
Health status and quality of life · bipolar disorder
1 finding from 1 review
Total severity score from depression and mania symptom scores, such as HDRS and the YMRS · bipolar disorder
1 finding from 1 review
Recurrence of any episodes at one year (Young Mania Rating Scale (YMRS) total score ≥15 for manic episode) · bipolar disorder
Lamotrigine may leads to lower recurrence of any episodes at one year (Young Mania Rating Scale… compared with placebo (low certainty).
1 finding from 1 review
Recurrence of any episodes at one year (Montgomery‐Asberg Depression Rating Scale (MADRS) total score ≥15 for depressive episode; Hamilton Depression Rating Scale (HDRS) total score ≥14 for depressive episode) · bipolar disorder
Lamotrigine showed no clear difference in recurrence of any episodes at one year (Montgomery‐Asberg Depression… compared with placebo (low certainty).
1 finding from 1 review
Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder
Lamotrigine probably leads to lower recurrence of any episodes at one year for clinical worsening with… compared with placebo (moderate certainty).
1 finding from 1 review
Recurrence of any episodes at one year (active suicidal behavior) · bipolar disorder
1 finding from 1 review
no estimate extracted
1 study · 1 participants
GRADE not reported
Treatment withdrawal · bipolar disorder
It is very uncertain whether lamotrigine changes withdrawal from treatment due to any reason, up to 12 weeks after… compared with placebo (very low certainty).
1 finding from 1 review
Withdrawal from treatment due to any reason, 6‐12 months after intervention initiation (long term) · bipolar disorder
Lamotrigine probably leads to lower withdrawal from treatment due to any reason, 6‐12 months after… compared with placebo (moderate certainty).
1 finding from 1 review