Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

927 questions · 1,014 findings · 29 reviews · Oral medicine and oral cancer

No studies found 123 · 12.1%GRADE not reported 604 · 59.6%Very low 193 · 19%Low 58 · 5.7%Moderate 35 · 3.5%High 1 · 0.1%

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no treatment

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) may leads to lower oral mucositis (any severity) compared with no treatment (low certainty).

1 finding from 1 review

Cryotherapy (ice chips) 30 minutes vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) 30 minutes showed no clear difference in oral mucositis (severe) compared with cryotherapy (ice chips) 60 minutes; GRADE not reported.

1 finding from 1 review

Chinese herbal medicines vs Control (Dobell's solution)

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chinese herbs (medicine) led to lower oral mucositis (any severity) compared with control (Dobell's solution); GRADE not reported.

1 finding from 1 review

Keratinocyte GF 50 mg vs Keratinocyte GF 25 mg

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Keratinocyte GF 50 mg showed no clear difference in oral mucositis (moderate to severe) compared with keratinocyte GF 25 mg; GRADE not reported.

1 finding from 1 review

Keratinocyte GF 50 mg vs Keratinocyte GF 25 mg

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Keratinocyte GF 50 mg showed no clear difference in oral mucositis (severe) compared with keratinocyte GF 25 mg; GRADE not reported.

1 finding from 1 review

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Chinese herbal medicines vs Control (Dobell's solution)

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chinese herbs (medicine) showed no clear difference in oral mucositis (severe) compared with control (Dobell's solution); GRADE not reported.

1 finding from 1 review

Antifungal drugs not absorbed from GI tract vs placebo or no treatment

Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs not absorbed from GI tract showed no clear difference in oral candidiasis (present) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review