Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

256 questions · 282 findings · 27 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 38 · 13.5%GRADE not reported 32 · 11.3%Very low 62 · 22%Low 64 · 22.7%Moderate 62 · 22%High 24 · 8.5%

Intervention not reported

IRI_BEV_RT vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

RT40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention may leads to lower RT40 (4 RCTs; 930 participants) (low certainty).

1 finding from 1 review

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention may leads to lower TMZ (3 RCTs, 538 participants) (low certainty).

1 finding from 1 review

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention led to lower CRT (2 RCTs; 635 participants); GRADE not reported.

1 finding from 1 review

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention led to lower BEV_CRT (1 RCT; 73 participants); GRADE not reported.

1 finding from 1 review

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention showed no clear difference in BEV_RT (1 RCT; 75 participants) (low certainty).

1 finding from 1 review