Findings

What do systematic reviews say?

304 questions · 310 findings · 24 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 96 · 31%GRADE not reported 20 · 6.5%Very low 83 · 26.8%Low 70 · 22.6%Moderate 30 · 9.7%High 11 · 3.5%

Summary of findings: bevacizumab vs placebo

Corticosteroid requirements · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Edaravone plus corticosteroids vs corticosteroids

Reduction in oedema (T2 hyperintensity) · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

Edaravone plus corticosteroids showed no clear difference in reduction in oedema (T2 hyperintensity) compared with corticosteroids (low certainty).

1 finding from 1 review

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
MD 3.03
1 study · 137 participants
Low

Edaravone plus corticosteroids vs corticosteroids

Reduction in post‐gadolinium enhancement · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

Edaravone plus corticosteroids showed no clear difference in reduction in post‐gadolinium enhancement compared with corticosteroids (low certainty).

1 finding from 1 review

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
MD 0.47
1 study · 137 participants
Low

Edaravone plus corticosteroids vs corticosteroids

Improvement in LENT/SOMA · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

Edaravone plus corticosteroids may leads to higher improvement in LENT/SOMA compared with corticosteroids (low certainty).

1 finding from 1 review

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
OR 2.51
1 study · 137 participants
Low

Exercise vs usual care

Physical fitness · People with cancer undergoing multimodal treatment including surgery

1 finding from 1 review

Exercise interventions for people undergoing multimodal cancer treatment that includes surgery 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 381 participants
Low

Exercise vs usual care

Safety · People with cancer undergoing multimodal treatment including surgery

1 finding from 1 review

Exercise interventions for people undergoing multimodal cancer treatment that includes surgery 2018 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 507 participants
Low

Exercise vs usual care

Health‐related quality of life · People with cancer undergoing multimodal treatment including surgery

1 finding from 1 review

Exercise interventions for people undergoing multimodal cancer treatment that includes surgery 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 472 participants
Moderate

Exercise vs usual care

Fatigue · People with cancer undergoing multimodal treatment including surgery

1 finding from 1 review

Exercise interventions for people undergoing multimodal cancer treatment that includes surgery 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 449 participants
Moderate

Exercise vs usual care

Postoperative outcome · People with cancer undergoing multimodal treatment including surgery

1 finding from 1 review

Exercise interventions for people undergoing multimodal cancer treatment that includes surgery 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Summary of findings: BT vs external beam radiotherapy (EBRT)

Acute and late GI toxicity (grade 2+) · People with urological (prostate) and gynaecological (endometrial) cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: BT vs external beam radiotherapy (EBRT)

Diarrhoea (grade 2+) · People with urological (prostate) and gynaecological (endometrial) cancer

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
0 participants
GRADE not reported

Summary of findings: BT vs external beam radiotherapy (EBRT)

QoL · People with urological (prostate) and gynaecological (endometrial) cancer

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 348 participants
GRADE not reported

Superoxide dismutase (SOD) vs no intervention

Mean GI symptom scores · people with Rectal Cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Superoxide dismutase (SOD) vs no intervention

Acute and late GI toxicity (grade 2+) · people with Rectal Cancer

Summary of findings: Superoxide dismutase may leads to lower acute and late GI toxicity (grade 2+) compared with no intervention (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.2 [0.05, 0.86]
1 study · 92 participants
Low

Superoxide dismutase (SOD) vs no intervention

Diarrhoea (grade 2+) · people with Rectal Cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Superoxide dismutase (SOD) vs no intervention

QoL · people with Rectal Cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo

Mean GI symptom scores · Men with prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo

Acute and late GI toxicity (grade 2+) · Men with prostate cancer

It is very uncertain whether summary of findings: Corticosteroids changes acute and late GI toxicity (grade 2+) compared with placebo (very low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.85 [0.62, 1.15]
1 study · 126 participants
Very low

Corticosteroids vs placebo

Diarrhoea (grade 2+) · Men with prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo

QoL · Men with prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found