Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

644 questions · 665 findings · 65 reviews · Developmental, Psychosocial and Learning Problems

No studies found 168 · 25.3%GRADE not reported 23 · 3.5%Very low 251 · 37.7%Low 148 · 22.3%Moderate 70 · 10.5%High 5 · 0.8%

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial
1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Relapse during intervention defined as admission to inpatient therapeutic care or recurrence of oedema or systematic infections during the study period, and dropouts during intervention period · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

It is very uncertain whether standard ready‐to‐use therapeutic food (RUTF) provided at a dose… changes relapse during intervention defined as admission to inpatient… compared with an alternative dietary approach (very low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Mortality during intervention · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

It is very uncertain whether standard ready‐to‐use therapeutic food (RUTF) provided at a dose… changes mortality during intervention compared with an alternative dietary approach (very low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial
1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Recovery during intervention defined as WHZ > 0 in 1 study; 100% weight for height in 1 study · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose… may leads to higher recovery during intervention defined as WHZ > 0 in 1 study; 100%… compared with as a supplement to the usual diet (low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Relapse during intervention defined as admission to inpatient therapeutic care or recurrence of oedema or systematic infections during the study period, and dropouts during intervention period · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose… may leads to lower relapse during intervention defined as admission to inpatient… compared with as a supplement to the usual diet (low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Mortality during intervention · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…

It is very uncertain whether standard ready‐to‐use therapeutic food (RUTF) provided at a dose… changes mortality during intervention compared with as a supplement to the usual diet (very low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…
1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Recovery during intervention defined as weight gain ≥ 15% in relation to baseline weight, absence of complications and oedema, and MUAC > 110 mm in 2 studies; MUAC > 12.4 cm without oedema in 1 study; WHZ ≥ 80% for two consecutive visits in 1 stud... · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

Standard ready‐to‐use therapeutic food (RUTF) showed no clear difference in recovery during intervention defined as weight gain ≥ 15% in… compared with RUTF using an alternative formulation (high certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

All‐cause morbidity · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in all‐cause morbidity (the most frequent event associated with the… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Summary of findings: NBAS or NBO vs control

Caregiver knowledge (related to infants' physical capacities, including reflexes and senses) Assessed at postintervention, using multiple choice factual questions; higher scores indicate better outcome · caregiver‐infant dyads
1 finding from 1 review

Group‐based parent training programmes vs control

Emotional and behavioural problems (parent report) Scales used: BSI‐II, BSQ, CAPES, CBCL, CBQ postintervention · young children

Group‐based parent training programmes showed no clear difference in emotional and behavioural problems (parent report) Scales used:… compared with control (low certainty).

1 finding from 1 review

Group‐based parent training programmes vs control

Externalising problems (parent report) Scales used: CBCL, ECBI postintervention · young children

Group‐based parent training programmes showed no clear difference in externalising problems (parent report) Scales used: CBCL, ECBI… compared with control (moderate certainty).

1 finding from 1 review

Group‐based parent training programmes vs control

Externalising problems ‐ hyperactivity‐inattention (parent report) Scales used: HSQ postintervention · young children

It is very uncertain whether group‐based parent training programmes changes externalising problems ‐ hyperactivity‐inattention (parent report)… compared with control (very low certainty).

1 finding from 1 review

Group‐based parent training programmes vs control

Internalising problems (parent report) Scale used: CAPES postintervention · young children

Group‐based parent training programmes showed no clear difference in internalising problems (parent report) Scale used: CAPES… compared with control (low certainty).

1 finding from 1 review

Group‐based parent training programmes vs control

Social skills (parent report) Scale used: VABS postintervention · young children

It is very uncertain whether group‐based parent training programmes changes social skills (parent report) Scale used: VABS postintervention compared with control (very low certainty).

1 finding from 1 review