Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Summary of findings table ‐ Cannabis vs placebo

Spasticity: number of participants reporting reduction of 30% in the spasticity NRS ( · health problem or population

Summary of findings table ‐ Cannabis probably leads to higher spasticity: number of participants reporting reduction of 30% in the… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Participant‐reported pain relief of 50% or greater · health problem or population

It is very uncertain whether summary of findings table ‐ Cannabis changes pain:number of participants reporting pain relief of 50% or greater… compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Patient Global Impression of Change much or very much improved · health problem or population

Summary of findings table ‐ Cannabis probably leads to higher PGIC:number of participants reporting much or very much improvement… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Cannabis vs placebo

Specific AEs: number of participants reporting drug tolerance ( · health problem or population

It is very uncertain whether summary of findings table ‐ Cannabis changes specific AEs: number of participants reporting drug tolerance ( compared with placebo (very low certainty).

1 finding from 1 review

Tocilizumab every 4 weeks vs placebo

Proportion of participants with sustained remission (as defined by study investigators) at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every 4 weeks probably leads to higher proportion of participants with sustained remission (as defined by… compared with placebo (moderate certainty).

1 finding from 1 review

Tocilizumab every 4 weeks vs placebo

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every 4 weeks showed no clear difference in adverse events at ≥ 12 months compared with placebo (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Proportion of participants with sustained remission (as defined by study investigators) at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly probably leads to higher proportion of participants with sustained remission (as defined by… compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Proportion of participants with relapse‐free survival at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly probably leads to higher proportion of participants with relapse‐free survival at ≥ 12 months compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review