Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,097 questions · 3,266 findings · 631 reviews

No studies found 430 · 13.2%GRADE not reported 193 · 5.9%Very low 995 · 30.5%Low 904 · 27.7%Moderate 591 · 18.1%High 153 · 4.7%

Perioperative beta‐blockers vs placebo or usual care

Myocardial infarction (0 to 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers may leads to lower acute myocardial infarction (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Cerebrovascular events (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers showed no clear difference in cerebrovascular events (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Ventricular arrhythmias (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

It is very uncertain whether perioperative beta‐blockers changes ventricular arrhythmias (within 30 days) compared with placebo or standard care (very low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Atrial fibrillation or atrial flutter, or both (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers may leads to lower atrial fibrillation or atrial flutter, or both (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Bradycardia · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers may leads to higher bradycardia (within 30 days; as defined by study authors, minimum… compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Hypotension · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers probably leads to higher hypotension (within 30 days; as defined by study authors, minimum… compared with placebo or standard care (moderate certainty).

1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs High-content fluoride toothpaste (1350 ppm)

Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review

Slow-release fluoride device (fluoride glass beads) vs placebo or usual care

Caries increment, surface index D(M)FS · Children with high risk of dental decay

It is very uncertain whether slow-release fluoride device (fluoride glass beads) changes increase in DMFS at 2 years compared with baseline compared with placebo or usual care (control) (very low certainty).

1 finding from 1 review

Slow-release fluoride device (fluoride glass beads) vs placebo or usual care

Caries increment, tooth index D(M)FT · Children with high risk of dental decay

It is very uncertain whether slow-release fluoride device (fluoride glass beads) changes increase in DMFT at 2 years compared with baseline compared with placebo or usual care (control) (very low certainty).

1 finding from 1 review

Intervention not reported

Primary outcome measure · mixed population (women with a fear of childbirth; women with high levels of anxiety; husbands of pregnant women; pregnant women and…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Caesarean section – emergency · mixed population (women with a fear of childbirth; women with high levels of anxiety; husbands of pregnant women; pregnant women and…

The intervention showed no clear difference in caesarean section – emergency (moderate certainty).

1 finding from 1 review

Intervention not reported

Caesarean section – elective repeat · mixed population (women with a fear of childbirth; women with high levels of anxiety; husbands of pregnant women; pregnant women and…
1 finding from 1 review

Intervention not reported

Caesarean section – for psychological reasons · mixed population (women with a fear of childbirth; women with high levels of anxiety; husbands of pregnant women; pregnant women and…

The intervention showed no clear difference in caesarean section – for psychological reasons (low certainty).

1 finding from 1 review

Intervention not reported

Caesarean section – overall · mixed population (women with a fear of childbirth; women with high levels of anxiety; husbands of pregnant women; pregnant women and…

It is very uncertain whether the intervention changes caesarean section – overall (very low certainty).

1 finding from 1 review

Intervention not reported

Caesarean section – VBAC · mixed population (women with a fear of childbirth; women with high levels of anxiety; husbands of pregnant women; pregnant women and…
1 finding from 1 review

Intervention not reported

Caesarean section – scheduled · mixed population (women with a fear of childbirth; women with high levels of anxiety; husbands of pregnant women; pregnant women and…

The intervention showed no clear difference in caesarean section – scheduled (moderate certainty).

1 finding from 1 review

Intervention not reported

Caesarean section – urgent · mixed population (women with a fear of childbirth; women with high levels of anxiety; husbands of pregnant women; pregnant women and…

The intervention showed no clear difference in caesarean section – urgent (moderate certainty).

1 finding from 1 review