What do systematic reviews say?

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs standard local care

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in major bleeding requiring transfusion of packed red blood cells compared with standard care (usual local haemostatic measures: gelatin sponge and…; GRADE not reported.

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes

  7 days
  RD 0.00 [-0.04, 0.04]
  2 studies · 125 participants
  GRADE not reported

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

The review found no eligible studies for this question.

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs standard local care

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in number of participants with postoperative bleedings requiring… compared with standard care (usual local haemostatic measures: gelatin sponge and… (moderate certainty).

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes

  7 days
  RD 0.02 [-0.07, 0.11]
  2 studies · 125 participants
  Moderate

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in number of minor postoperative bleeding episodes compared with placebo (placebo solution/mouthwash); GRADE not reported.

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes

  7 days
  RD -0.06 [-0.33, 0.20]
  2 studies · 128 participants
  GRADE not reported

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

The review found no eligible studies for this question.

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in side effects or other adverse events requiring withdrawal compared with placebo (placebo solution/mouthwash) (moderate certainty).

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes

  7 days
  RD 0.00 [-0.04, 0.04]
  2 studies · 128 participants
  Moderate

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

The review found no eligible studies for this question.

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Antifibrinolytic agents (tranexamic acid (TXA) or epsilon aminocaproic acid (EACA)) vs Placebo, no intervention, or usual care

The review found no eligible studies for this question.

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Intervention not reported

• Prosthetic rehabilitation for older dysvascular people following a unilateral transfemoral amputation 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 10 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Prosthetic rehabilitation for older dysvascular people following a unilateral transfemoral amputation 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Mesh vs non‐mesh repair

Mesh probably leads to lower hernia recurrence compared with non‐mesh repair (moderate certainty).

• Mesh versus non‐mesh for inguinal and femoral hernia repair 2018 · Cochrane Headline outcomes only
  RR 0.46 [0.26, 0.8]
  21 studies · 5575 participants
  Moderate

Mesh vs non‐mesh repair

Mesh leads to lower surgical complications ‐ neurovascular or visceral injury compared with non‐mesh repair (high certainty).

• Mesh versus non‐mesh for inguinal and femoral hernia repair 2018 · Cochrane Headline outcomes only
  RR 0.61 [0.49, 0.76]
  24 studies · 6293 participants
  High

Mesh vs non‐mesh repair

Mesh showed no clear difference in surgical complications ‐ wound infection compared with non‐mesh repair (low certainty).

• Mesh versus non‐mesh for inguinal and femoral hernia repair 2018 · Cochrane Headline outcomes only
  RR 1.29 [0.89, 1.86]
  21 studies · 4540 participants
  Low

Mesh vs non‐mesh repair

Mesh showed no clear difference in surgical complications ‐ wound dehiscence compared with non‐mesh repair (low certainty).

• Mesh versus non‐mesh for inguinal and femoral hernia repair 2018 · Cochrane Headline outcomes only
  RR 0.55 [0.12, 2.48]
  2 studies · 329 participants
  Low

Mesh vs non‐mesh repair

The review found no eligible studies for this question.

• Mesh versus non‐mesh for inguinal and femoral hernia repair 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Mesh vs non‐mesh repair

• Mesh versus non‐mesh for inguinal and femoral hernia repair 2018 · Cochrane Headline outcomes only
  no estimate extracted
  20 studies · 4148 participants
  Very low

Mesh vs non‐mesh repair

• Mesh versus non‐mesh for inguinal and femoral hernia repair 2018 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 2966 participants
  Low

Mesh vs non‐mesh repair

• Mesh versus non‐mesh for inguinal and femoral hernia repair 2018 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 3183 participants
  Low

Mesh vs non‐mesh repair

• Mesh versus non‐mesh for inguinal and femoral hernia repair 2018 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1680 participants
  Low

Transradial vs transfemoral approach

Transradial probably leads to lower short‐term NACE compared with transfemoral approach (moderate certainty).

• Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in… 2018 · Cochrane Headline outcomes only
  RR 0.76 [0.61, 0.94]
  4 studies · 17133 participants
  Moderate