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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Twin Block functional appliance vs Modified Twin Block appliances

Final overjet · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Twin Block functional appliance (conventional) showed no clear difference in final overjet compared with modified Twin Block appliances; GRADE not reported.

1 finding from 1 review

Late treatment (one-phase) with fixed functional appliance vs no treatment

Incidence of incisal trauma · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

The review found no eligible studies for this question.

1 finding from 1 review

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Velopharyngeal function (complete velopharyngeal closure; deterioration/improvement) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…

It is very uncertain whether maxillary distraction osteogenesis changes velopharyngeal function (complete velopharyngeal closure;… compared with orthognathic surgery (conventional Le Fort I osteotomy) (very low certainty).

1 finding from 1 review

Routine scale and polish every 6 months vs Routine scale and polish every 12 months

Probing pocket depth · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

Routine scale and polish every 6 months showed no clear difference in probing depth compared with routine scale and polish every 12 months (high certainty).

1 finding from 1 review

Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method

Maxillary denture satisfaction · Completely edentulous people

It is very uncertain whether single-stage alginate impression (simplified method) changes maxillary denture satisfaction compared with two stage-two step elastomer (silicone, polysulfide, or polyether)… (very low certainty).

1 finding from 1 review

Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method

Oral health-related quality of life · Completely edentulous people

It is very uncertain whether single-stage alginate impression (simplified method) changes participant-reported oral health-related quality of life (OHIP-EDENT) compared with two stage-two step elastomer (silicone, polysulfide, or polyether)… (very low certainty).

1 finding from 1 review

Enhanced one-to-one OHA vs Routine one-to-one OHA

Patient-reported changes in knowledge, attitudes and quality of life · Children or adults (fit and healthy, or with a well-defined medical condition)
1 finding from 1 review

Fixed functional appliance (FORSUS FRD) vs Intermaxillary elastics

Final ANB · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Fixed functional appliance (FORSUS FRD) showed no clear difference in final ANB compared with intermaxillary elastics; GRADE not reported.

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Buffered glutaraldehyde

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
  • Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
    6 months
    Assessed pain, soft tissue, mobility, radiolucency, root resorption, pulp canal obliteration (Goyal 2016); no clinical/radiological failure outcome; pain, mobility, radiolucency, root resorption significantly favour MTA
    1 study · 60 participants
    GRADE not reported

Mineral trioxide aggregate (MTA) vs Diode laser

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
  • Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
    6 months
    Assessed pain, soft tissue, mobility, radiolucency, root resorption, premature tooth loss (Niranjani 2015); no clinical/radiological failure outcome; no significant differences (RR 0.33, 0.01 to 7.72)
    1 study · 40 participants
    GRADE not reported

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy vs 3Mix pulpectomy

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in clinical failure compared with 3Mix pulpectomy; GRADE not reported.

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Any postoperative complication except bleeding (e.g. wound infection) · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in any postoperative complication except bleeding (e.g. wound infection) compared with placebo (placebo solution/mouthwash); GRADE not reported.

1 finding from 1 review