Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

PFS: hormone receptor‐negativemedian · people with metastatic breast cancer

Capecitabine‐containing regimens showed no clear difference in PFS: hormone receptor‐negativemedian compared with chemotherapy regimens without capecitabine (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Objective response rate · people with metastatic breast cancer

Capecitabine‐containing regimens showed no clear difference in objective response rate compared with chemotherapy regimens without capecitabine (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Proportion of children with inadequate level of sedation (Ramsay score below 4) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) may leads to lower proportion of children with inadequate level of sedation (Ramsay… compared with promethazine oral (1 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) probably leads to lower proportion of children who had sedation failure or inadequate level… compared with promethazine oral (1 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Number of children with clinical adverse event: behavioural change · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) showed no clear difference in number of children with clinical adverse event: behavioural change compared with promethazine oral (1 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Number of children with clinical adverse event: nausea or vomiting · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) showed no clear difference in number of children with clinical adverse event: vomiting or nausea compared with promethazine oral (1 mg/kg) (low certainty).

1 finding from 1 review

Surface‐modified vs standard catheter

Death from any cause at day 28 of · AKI patients receiving CKRT

It is very uncertain whether surface‐modified changes death from any cause at day 28 of compared with standard double‐lumen catheter with identical geometry and flow design (very low certainty).

1 finding from 1 review

Surface‐modified vs standard catheter

Recovery of kidney function · AKI patients receiving CKRT

Surface‐modified showed no clear difference in recovery of kidney function compared with standard double‐lumen catheter with identical geometry and flow design (low certainty).

1 finding from 1 review

Surface‐modified vs standard catheter

Vascular access complications · AKI patients receiving CKRT

Surface‐modified showed no clear difference in vascular access complications compared with standard double‐lumen catheter with identical geometry and flow design (low certainty).

1 finding from 1 review

Oral misoprostol vs mechanical methods

Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in uterine hyperstimulation with fetal heart rate changes compared with mechanical methods (low certainty).

1 finding from 1 review

Oral misoprostol vs mechanical methods

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes uterine hyperstimulation without fetal heart rate changes compared with mechanical methods (very low certainty).

1 finding from 1 review