Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

ANY FAMILY BASED INTERVENTIONS (>5 sessions) vs usual care

Social functioning: Specific ‐ unemployed ‐ at about 1 year · patients with schizophrenia

ANY FAMILY BASED INTERVENTIONS (>5 sessions) showed no clear difference in social functioning: Specific ‐ unemployed ‐ at about 1 year compared with STANDARD CARE (low certainty).

1 finding from 1 review

ANY FAMILY BASED INTERVENTIONS (>5 sessions) vs usual care

Social functioning: Specific ‐ unable to live independently ‐ at about 1 year · patients with schizophrenia

ANY FAMILY BASED INTERVENTIONS (>5 sessions) showed no clear difference in social functioning: Specific ‐ unable to live independently ‐ at… compared with STANDARD CARE (low certainty).

1 finding from 1 review

ANY FAMILY BASED INTERVENTIONS (>5 sessions) vs usual care

Family outcome: Burden ‐ not improved/worse (objective burden related to self‐sufficiency) · patients with schizophrenia

It is very uncertain whether ANY FAMILY BASED INTERVENTIONS (>5 sessions) changes family outcome: Burden ‐ not improved/worse (objective burden… compared with STANDARD CARE (very low certainty).

1 finding from 1 review

ZOTEPINE vs REMOXIPRIDE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · patients with schizophrenia

ZOTEPINE showed no clear difference in adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with REMOXIPRIDE (low certainty).

1 finding from 1 review

ZOTEPINE vs CLOZAPINE

Global state: No clinically important response (as defined by the original studies) · patients with schizophrenia

It is very uncertain whether ZOTEPINE changes global state: No clinically important response (as defined by the… compared with CLOZAPINE (very low certainty).

1 finding from 1 review

ZOTEPINE vs CLOZAPINE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · patients with schizophrenia

It is very uncertain whether ZOTEPINE changes adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with CLOZAPINE (very low certainty).

1 finding from 1 review

ZOTEPINE vs RISPERIDONE

Adverse effects: Extrapyramidal effects ‐ use of antiparkinson medication ‐ vs 4mg risperidone · patients with schizophrenia

It is very uncertain whether ZOTEPINE changes adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

ZOTEPINE vs RISPERIDONE

Adverse effects: Extrapyramidal effects ‐ use of antiparkinson medication ‐ vs 8mg risperidone · patients with schizophrenia

It is very uncertain whether ZOTEPINE changes adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

SWITCHING ‐ NEW ANTIPSYCHOTIC REGIMEN vs CONTINUATION ON PREVIOUS REGIMEN: 1b. NEW ATYPICAL from OLANZAPINE ‐ medium term (3‐12 months)

Weight: 2a. BMI ‐ Increase · patients with people with schizophrenia who have neuroleptic‐induced weight or metabolic problems

It is very uncertain whether SWITCHING ‐ NEW ANTIPSYCHOTIC REGIMEN changes weight: 2a. BMI ‐ Increase compared with CONTINUATION ON PREVIOUS REGIMEN: 1b. NEW ATYPICAL from OLANZAPINE ‐… (very low certainty).

1 finding from 1 review

SWITCHING ‐ NEW ANTIPSYCHOTIC REGIMEN vs CONTINUATION ON PREVIOUS REGIMEN: 1b. NEW ATYPICAL from OLANZAPINE ‐ medium term (3‐12 months)

Physiological measures: 1c. Average fasting glucose change ‐ switching to aripiprazole and quetiapine · patients with people with schizophrenia who have neuroleptic‐induced weight or metabolic problems
1 finding from 1 review

SWITCHING ‐ NEW ANTIPSYCHOTIC REGIMEN vs CONTINUATION ON PREVIOUS REGIMEN: 1b. NEW ATYPICAL from OLANZAPINE ‐ medium term (3‐12 months)

Relapse · patients with people with schizophrenia who have neuroleptic‐induced weight or metabolic problems

SWITCHING ‐ NEW ANTIPSYCHOTIC REGIMEN showed no clear difference in global state: Relapse compared with CONTINUATION ON PREVIOUS REGIMEN: 1b. NEW ATYPICAL from OLANZAPINE ‐… (low certainty).

1 finding from 1 review