What do systematic reviews say?

Intraoral device releasing Biotene Oral Balance gel vs usual care without an aid

Intraoral device releasing Biotene Oral Balance gel showed no clear difference in salivary flow (unstimulated whole saliva) compared with usual care (no intraoral device); GRADE not reported.

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  MD 0.05 [-0.04, 0.14]
  1 study · 30 participants
  GRADE not reported

Sucralfate vs placebo or usual care

Sucralfate showed no clear difference in oral mucositis (moderate to severe) compared with placebo/usual care; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.75 [0.54, 1.04]
  4 studies
  GRADE not reported

Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs usual care

Psychosocial interventions (cognitive behavioural therapy,… led to lower pain intensity (long term) compared with usual care (conservative treatment: education, counselling,…; GRADE not reported.

• Psychosocial interventions for the management of chronic orofacial pain 2011 · Cochrane All outcomes

  Long term (more than 3 months)
  SMD -0.34 [-0.50, -0.18]
  7 studies · 658 participants
  GRADE not reported

Intraoral device releasing Biotene Oral Balance gel vs usual care without an aid

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Frost 2002 (crossover, n=30, Sjogren's syndrome): overall mouth dryness favoured the device but only nearly significant (median 4 (IQR 2 to 4) device vs 3 (2 to 4) control; P = 0.056). Speech (P = 0.003) and swallowing…
  1 study · 30 participants
  GRADE not reported

Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs usual care

Psychosocial interventions (cognitive behavioural therapy,… showed no clear difference in muscle palpation pain (long term) compared with usual care (conservative treatment: education, counselling,…; GRADE not reported.

• Psychosocial interventions for the management of chronic orofacial pain 2011 · Cochrane All outcomes

  Long term (more than 3 months)
  Muscle palpation pain long term (greater than 3 months): 3 studies; results not pooled owing to substantial heterogeneity (I2=64%); insufficient evidence to draw conclusions for any individual intervention. One study…
  3 studies
  GRADE not reported

Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs usual care

Psychosocial interventions (cognitive behavioural therapy,… led to lower depression (long term) compared with usual care (conservative treatment: education, counselling,…; GRADE not reported.

• Psychosocial interventions for the management of chronic orofacial pain 2011 · Cochrane All outcomes

  Long term (more than 3 months)
  SMD -0.35 [-0.54, -0.16]
  6 studies · 455 participants
  GRADE not reported

Glutamine vs placebo or usual care

Glutamine showed no clear difference in oral mucositis (moderate to severe) compared with placebo/usual care; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.88 [0.69, 1.12]
  5 studies
  GRADE not reported

Glutamine vs placebo or usual care

Glutamine showed no clear difference in oral mucositis (severe) compared with placebo/usual care; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.69 [0.37, 1.29]
  5 studies
  GRADE not reported

Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs usual care

Psychosocial interventions (cognitive behavioural therapy,… led to higher pain intensity (short term) compared with usual care (conservative treatment: education, counselling,…; GRADE not reported.

• Psychosocial interventions for the management of chronic orofacial pain 2011 · Cochrane All outcomes

  Short term (3 months or less) · Combination CBT/biofeedback
  SMD 0.46 [0.02, 0.90]
  2 studies · 90 participants
  GRADE not reported

Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs usual care

Psychosocial interventions (cognitive behavioural therapy,… led to lower pain severity - impact: activity interference / disability (long term) compared with usual care (conservative treatment: education, counselling,…; GRADE not reported.

• Psychosocial interventions for the management of chronic orofacial pain 2011 · Cochrane All outcomes

  Long term (more than 3 months) · CBT alone
  SMD -0.27 [-0.51, -0.03]
  4 studies · 285 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997 observed and rated participants on flossing skill; Analysis of Covariance found a significant difference favouring the intervention group.
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  The impact of psychological interventions on clinical markers was assessed in three studies (Little 1997; Stewart 1991; Weinstein 1996). All three found that psychological interventions resulted in improved plaque…
  3 studies
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  Stewart 1996: the psychological intervention group demonstrated significantly higher change in self efficacy scores for flossing at post-intervention compared to the other two groups (control and educational). Flossing…
  1 study · 117 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997: no change in pocket depth; there were no differences between the intervention and control groups in overall change in pocket depth. (Some analyses suggested greater change in the intervention group when…
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997 reported decreased gingival bleeding in the active intervention group: gingival bleeding present in 9% of the intervention group at baseline and 4% at 4-month follow up, versus 10% of the control group on…
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997: no change in attachment loss; no differences between the intervention and control groups in overall change in attachment (loss of attachment) markers.
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes

  4 months
  Little 1997 observed and rated participants on brushing skill; Analysis of Covariance found a significant difference favouring the intervention group (one of four measures on which significant differences were found…
  1 study · 107 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  Stewart 1996: for dental knowledge the control group showed no change pre- and post-intervention, whereas the psychological intervention group improved dental knowledge significantly (both intervention groups improved…
  1 study · 117 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  Stewart 1996: the psychological intervention had no discernible effect on self efficacy beliefs concerning tooth brushing; the data on perceived self efficacy for tooth brushing were not analysed due to ceiling effects…
  1 study · 117 participants
  GRADE not reported

Psychological intervention based on a specified psychological model/theory (to increase adherence to oral hygiene instructions) vs usual care or no treatment

• Psychological interventions to improve adherence to oral hygiene instructions in adults with periodontal diseases 2007 · Cochrane All outcomes
  Self assessed flossing was assessed in two studies (Little 1997; Stewart 1991); both reported improvements for the intervention groups. Little 1997: Analysis of Covariance found significant differences favouring the…
  2 studies
  GRADE not reported