Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

253 questions · 256 findings · 57 reviews · Pregnancy and Childbirth

No studies found 22 · 8.6%GRADE not reported 10 · 3.9%Very low 32 · 12.5%Low 95 · 37.1%Moderate 67 · 26.2%High 30 · 11.7%

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

A7: Severe lung disease – all fetuses randomised · the fetus/neonate/infant

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid probably leads to lower A7: Severe lung disease – all fetuses randomised compared with single course (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Chronic lung disease · the fetus/neonate/infant

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A8: Chronic lung disease – all fetuses randomised compared with single course (high certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Intraventricular haemorrhage, Papile grade 3/4 · the fetus/neonate/infant

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A9: Severe intraventricular haemorrhage (grade 3 or 4) – all fetuses… compared with single course (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Necrotising enterocolitis · the fetus/neonate/infant

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A11: Necrotising enterocolitis – all fetuses randomised compared with single course (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

A12: Composite of serious outcomes– all fetuses randomised · the fetus/neonate/infant

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid probably leads to lower A12: Composite of serious outcomes– all fetuses randomised compared with single course (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Maternal death · the woman

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids showed no clear difference in B1: Maternal death – all women compared with single course (low certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

B2: Maternal sepsis – an all women · the woman

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids showed no clear difference in B2: Maternal sepsis – an all women compared with single course (moderate certainty).

1 finding from 1 review