Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

592 questions · 604 findings · 53 reviews · Headline outcomes only

No studies found 151 · 25%GRADE not reported 31 · 5.1%Very low 94 · 15.6%Low 170 · 28.1%Moderate 114 · 18.9%High 44 · 7.3%

Probiotics vs other active intervention

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

It is very uncertain whether probiotics changes requiring rescue medication for diarrhoea compared with other active treatment (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Median (mean) time to use of rescue medication · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Probiotics vs placebo

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics showed no clear difference in requiring rescue medication for diarrhoea compared with placebo (moderate certainty).

2 findings from 1 review

Probiotics vs placebo

Adverse events · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Probiotics vs placebo

All‐cause mortality · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Moxibustion vs no treatment

The incidence and severity of toxicities: leukopenia (WHO grade 3 to 4) · Patients with cancer receiving chemotherapy and/or radiotherapy

Moxibustion showed no clear difference in the incidence and severity of toxicities: leukopenia (WHO grade 3 to… compared with no treatment (low certainty).

1 finding from 1 review

Moxibustion vs Western medicine

The incidence and severity of toxicities: haematological toxicity · Patients with cancer receiving chemotherapy and/or radiotherapy

Moxibustion showed no clear difference in the incidence and severity of toxicities: haematological toxicity compared with conventional medicines (low certainty).

1 finding from 1 review