Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in maximal mouth opening (interincisal distance) compared with placebo or no active treatment (low certainty).
3 findings from 1 review
MD -1.41 [-5.74, 2.92]
1 study · 90 participants
Low
MD 3.11 [0.46, 5.77]
2 studies · 520 participants
Low
MD 8.83 [8.22, 9.45]
3 studies · 620 participants
Moderate
Change in gingival recession (REC) · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
It is very uncertain whether adjunctive antimicrobial photodynamic therapy (aPDT) applied after… changes change in gingival recession (REC) compared with subgingival instrumentation (SI) alone (hand or power-driven, or… (very low certainty).
2 findings from 1 review
Percussion pain at 72 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in percussion pain at 72 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review
Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
3 findings from 1 review
No studies measured this outcome for root surfaces
0 studies
No studies found
Peto OR 44.22 [33.12, 59.04]
1 study · 663 participants
Very low
OR 1.08 [0.52, 2.23]
1 study · 128 participants
Very low
Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Pentoxifylline led to lower difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Discomfort/pain · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Difficulty in swallowing (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Pentoxifylline led to lower difficulty in swallowing (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with placebo or no treatment (very low certainty).
3 findings from 1 review
MD -1.14 [-1.58, -0.70]
1 study · 373 participants
Very low
MD -0.79 [-1.40, -0.17]
3 studies · 439 participants
Moderate
MD -0.69 [-0.97, -0.41]
1 study · 373 participants
Very low
Severity of joint noise · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes severity of joint noise compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).
1 finding from 1 review
Depression · People with temporomandibular disorders (TMD)
Occlusal splint led to lower depression compared with no treatment or placebo (non-occlusal or transparent-foil placebo…; GRADE not reported.
1 finding from 1 review
Change in probing pocket depth (PPD) · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… showed no clear difference in change in probing depth (PD/PPD) compared with submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT; GRADE not reported.
1 finding from 1 review
Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT
Outcome not reported · Adults (> 18 years) with peri-implantitis, receiving supportive treatment
The review found no eligible studies for this question.
1 finding from 1 review
Analgesic (painkiller) use · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
Single preoperative dose of systemic antibiotics (clindamycin 600… showed no clear difference in analgesic use compared with matched placebo, total chemo-mechanical debridement and root filling; GRADE not reported.
1 finding from 1 review
Patient satisfaction · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Percussion pain at 7 days · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in percussion pain at 7 days compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether intralesional dexamethasone injections changes maximal mouth opening (interincisal distance) compared with placebo injections (very low certainty).
2 findings from 1 review
Quality of life · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
The review found no eligible studies for this question.
1 finding from 1 review
Any adverse effect related to aPDT · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review