Findings

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Evidence found and GRADE certainty

283 questions · 285 findings · 33 reviews · Epilepsy

No studies found 31 · 10.9%GRADE not reported 13 · 4.6%Very low 33 · 11.6%Low 80 · 28.1%Moderate 96 · 33.7%High 32 · 11.2%

Lamotrigine vs carbamazepine

Time to 12‐month remission ‐ all participants Range of · adults and children with focal onset or generalised onset seizures (generalised tonic‐clonic with or without other generalised seizure…

Summary of findings: lamotrigine showed no clear difference in time to 12‐month remission All participants Range of compared with carbamazepine (high certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to treatment failure (any reason related to treatment) All participants Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine probably leads to lower time to treatment failure (any reason related to treatment) All… compared with phenobarbitone (moderate certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine may leads to lower time to treatment failure (any reason related to treatment)… compared with phenobarbitone (low certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to treatment failure (any reason related to treatment) Subgroup: generalised onset seizures (tonic‐clonic only) Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenobarbitone (low certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to first seizure (post‐randomisation) All participants Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine showed no clear difference in time to first seizure (post‐randomisation) All participants Range of compared with phenobarbitone (moderate certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine probably leads to higher time to first seizure (post‐randomisation) Subgroup: focal onset… compared with phenobarbitone (moderate certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to first seizure (post‐randomisation) ‐ stratified by epilepsy type: generalised onset seizures (tonic‐clonic only) Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine showed no clear difference in time to first seizure (post‐randomisation) Subgroup: generalised… compared with phenobarbitone (low certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to achieve 12‐month remission (seizure‐free period) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) Subgroup:… compared with phenobarbitone (low certainty).

1 finding from 1 review

Carbamazepine vs phenobarbitone

Time to 12‐month remission ‐ stratified by epilepsy type ‐ Generalized onset seizures (tonic‐clonic only) Range of · adults and children with newly onset partial or generalised epilepsy

Carbamazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) Subgroup:… compared with phenobarbitone (low certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to treatment failure (any reason related to treatment) All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to treatment failure (any reason related to treatment) All… compared with phenytoin (primary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to achieve 12‐month remission (seizure‐free period) Subgroup: focal onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) Subgroup:… compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to 12‐month remission ‐ stratified by epilepsy type ‐ generalised onset Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) Subgroup:… compared with phenytoin (secondary outcomes) (low certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenytoin (primary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to treatment failure (any reason related to treatment) Subgroup: generalised onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenytoin (primary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to treatment failure due to adverse events All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine leads to lower time to treatment failure due to adverse events All participants… compared with phenytoin (primary outcomes) (high certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to treatment failure due to lack of efficacy All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to treatment failure due to lack of efficacy All participants… compared with phenytoin (primary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) All participants Range of compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) Subgroup: focal onset… compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) Subgroup: generalised onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) Subgroup: generalised… compared with phenytoin (secondary outcomes) (low certainty).

1 finding from 1 review