Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,017 questions · 1,061 findings · 131 reviews

No studies found 193 · 18.2%GRADE not reported 65 · 6.1%Very low 237 · 22.3%Low 325 · 30.6%Moderate 187 · 17.6%High 54 · 5.1%

IVIg vs acetylsalicylic acid (ASA)

Incidence of any adverse effects after treatment initiation ( · people undergoing initial treatment for KD

It is very uncertain whether primary treatment with intravenous immunoglobulin (IVIG) changes incidence of any adverse effects after treatment initiation (from 30… compared with acetylsalicylic acid (ASA) (very low certainty).

1 finding from 1 review

IVIg vs different infusion regimens of IVIG

Incidence of any adverse effects after treatment initiation ( · people undergoing initial treatment for KD

Primary treatment with intravenous immunoglobulin (IVIG) showed no clear difference in incidence of any adverse effects after treatment initiation ( compared with different infusion regimens of IVIG (low certainty).

1 finding from 1 review

Intravenous immunoglobulin with or without standard care vs placebo or usual care

Significant disability assessed using Liverpool Outcome Score RR (M‐H, random‐effects analysis, 95% CI) · children with acute encephalitis

It is very uncertain whether intravenous immunoglobulin with or without standard care changes significant disability assessed using Liverpool Outcome Score RR… compared with standard care alone or placebo (very low certainty).

1 finding from 1 review

Intravenous immunoglobulin with or without standard care vs placebo or usual care

Serious adverse events Analysis 11.2 · children with acute encephalitis

It is very uncertain whether intravenous immunoglobulin with or without standard care changes ≥ 1 serious adverse event RR (M‐H, random‐effects analysis, 95% CI) compared with standard care alone or placebo (very low certainty).

1 finding from 1 review

Intravenous dexamethasone vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review

Intravenous dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block

The review found no eligible studies for this question.

1 finding from 1 review

IVIg vs placebo

Death · adults with renal vasculitis

Intravenous immunoglobulin showed no clear difference in death compared with placebo (low certainty).

1 finding from 1 review