Summary of findings ‐ DVD plus information booklet vs information booklet alone
QoL · adults and children with hemophilia
1 finding from 1 review
- no estimate extracted1 study · 108 participantsLow
Findings
What do systematic reviews say?
280 questions · 280 findings · 13 reviews · Cystic Fibrosis and Genetic Disorders
No studies found 127 · 45.4%GRADE not reported 3 · 1.1%Very low 85 · 30.4%Low 46 · 16.4%Moderate 19 · 6.8%High 0 · 0%
Summary of findings ‐ DVD plus information booklet vs information booklet alone
Compliance or adherence to the trial intervention (including satisfaction): use of intervention at least once · adults and children with hemophilia
Summary of findings ‐ DVD plus information booklet showed no clear difference in compliance or adherence to the trial intervention (including… compared with information booklet alone (low certainty).
1 finding from 1 review
- RR 1.02 [0.81, 1.28]1 study · 108 participantsLow
Summary of findings ‐ DVD plus information booklet vs information booklet alone
Physical health: pain intensity (VAS post‐treatment scores) · adults and children with hemophilia
1 finding from 1 review
- no estimate extracted1 study · 108 participantsLow
Summary of findings ‐ DVD plus information booklet vs information booklet alone
Cost of psychological intervention · adults and children with hemophilia
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings ‐ DVD plus information booklet vs information booklet alone
Family adjustment · adults and children with hemophilia
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings ‐ computerised learning vs no intervention
Self‐efficacy · adults and children with hemophilia
1 finding from 1 review
- no estimate extracted3 studies · 87 participantsVery low
Summary of findings ‐ computerised learning vs no intervention
Coping strategies: disease specific knowledge, practical skills, self management ability and transition readiness · adults and children with hemophilia
1 finding from 1 review
- no estimate extracted2 studies · 47 participantsLow
Long‐term red cell transfusion vs usual care
Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and normal TCD velocities
Long‐term RBC transfusion showed no clear difference in proportion of participants developing new or progressive SCI lesions compared with standard care (low certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyRR 0.7 [0.23, 2.13]1 study · 196 participantsLow
Long‐term red cell transfusion vs usual care
SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD and abnormal TCD velocities
Long‐term RBC transfusion may leads to lower SCD ‐ related SAEs ‐ ACS compared with standard care (low certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyRR 0.3 [0.11, 0.87]1 study · 130 participantsLow
Long‐term red cell transfusion vs usual care
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and abnormal TCD velocities
It is very uncertain whether long‐term RBC transfusion changes SCD‐related SAEs ‐ pain crisis compared with standard care (very low certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyRR 0.9 [0.44, 1.86]1 study · 130 participantsVery low
Long‐term red cell transfusion vs usual care
Stroke · prevention of SCI in people with SCD and abnormal TCD velocities
Long‐term RBC transfusion may leads to lower clinical stroke compared with standard care (low certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyRR 0.1 [0.01, 0.73]1 study · 130 participantsLow
Long‐term red cell transfusion vs usual care
Cognitive function ‐ not reported · prevention of SCI in people with SCD and abnormal TCD velocities
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Long‐term red cell transfusion vs usual care
Quality of life ‐ not reported · prevention of SCI in people with SCD and abnormal TCD velocities
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Long‐term red cell transfusion vs usual care
SCD ‐ related SAEs ‐ ACS · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions
Long‐term RBC transfusions may leads to lower SCD ‐ related SAEs ‐ ACS compared with standard care (low certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyRR 0.24 [0.12, 0.49]2 studies · 326 participantsLow
Long‐term red cell transfusion vs usual care
SCD‐related SAEs ‐ pain crisis · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions
Long‐term RBC transfusions may leads to lower SCD‐related SAEs ‐ pain crisis compared with standard care (low certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyRR 0.63 [0.42, 0.95]2 studies · 326 participantsLow
Long‐term red cell transfusion vs usual care
Stroke · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions
Long‐term RBC transfusions probably leads to lower clinical stroke compared with standard care (moderate certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyRR 0.12 [0.03, 0.49]2 studies · 326 participantsModerate
Transfusions continued vs transfusions halted
Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and normalised TCD velocities
Transfusions continued may leads to lower proportion of participants developing new or progressive SCI lesions compared with transfusions halted (low certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyRR 0.29 [0.09, 0.97]1 study · 77 participantsLow
Transfusions continued vs transfusions halted
All‐cause mortality · prevention of SCI in people with SCD and normalised TCD velocities
It is very uncertain whether transfusions continued changes all‐cause mortality compared with transfusions halted (very low certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyPeto OR 8 [0.16, 404.12]1 study · 79 participantsVery low
Long‐term red cell transfusion vs usual care
All‐cause mortality · prevention of SCI in people with SCD and normal TCD velocities
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 196 participantsLow
Transfusions continued vs transfusions halted
Stroke · prevention of SCI in people with SCD and normalised TCD velocities
It is very uncertain whether transfusions continued changes clinical stroke compared with transfusions halted (very low certainty).
1 finding from 1 review
- Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes onlyRR 0.22 [0.01, 4.35]1 study · 79 participantsVery low