Findings

What do systematic reviews say?

224 questions · 272 findings · 31 reviews · Dental caries

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No studies found 23 · 8.5%GRADE not reported 170 · 62.5%Very low 64 · 23.5%Low 6 · 2.2%Moderate 9 · 3.3%High 0 · 0%

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less

1 finding from 1 review

Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
Data on adverse effects (stain score, proportion of children with tooth staining, signs of sensitivity in oral soft tissue, adverse symptoms such as nausea/vomiting, etching of enamel) were reported in only a few…
Studies not reported
GRADE not reported

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects: dental fluorosis · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
Fluorosis data have not been reported in any of the trials.
0 studies
No studies found

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
During trial · No-treatment-controlled trials
RR 1.20 [0.85, 1.70]
10 studies
GRADE not reported

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Proportion developing new caries · Children and adolescents aged 16 years or younger (permanent dentition)

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… led to lower proportion of children developing one or more new caries compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
RR 0.88 [0.82, 0.95]
13 studies
GRADE not reported