Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

442 questions · 468 findings · 55 reviews

No studies found 96 · 20.5%GRADE not reported 54 · 11.5%Very low 172 · 36.8%Low 87 · 18.6%Moderate 40 · 8.5%High 19 · 4.1%

Highest vs lowest selenium exposure

Lung cancer risk (17 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in lung cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Breast cancer risk (14 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in breast cancer risk No. of participants: 802 (1 RCT) compared with lowest selenium exposure (moderate certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Bladder cancer risk No. of participants: 19,009 (2 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in bladder cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Prostate cancer risk (13 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in prostate cancer risk No. of participants: 18,942 (4 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Any cancer risk No. of participants: 76,239 (7 observational studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes any cancer risk No. of participants: 76,239 (7 observational studies) compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Intervention not reported

Immediate change in level in year 2000 (noise level at work as PEL dose in dB(A); range 0 to 6400, log scale) · workers with noise exposure
1 finding from 1 review

Intervention not reported

Change in slope after introduction (noise level at work as PEL dose in dB(A); range 0 to 6400, log scale) · workers with noise exposure
1 finding from 1 review

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Improvement in nutritional intake · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Any experimental intervention (surgical or non-surgical) vs active control

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Improvement of pre-existing accompanying symptoms other than pain · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review